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8EFL

SR17018-bound mu-opioid receptor-Gi complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001664molecular_functionG protein-coupled receptor binding
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005813cellular_componentcentrosome
A0005834cellular_componentheterotrimeric G-protein complex
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0016020cellular_componentmembrane
A0019001molecular_functionguanyl nucleotide binding
A0019003molecular_functionGDP binding
A0030496cellular_componentmidbody
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031749molecular_functionD2 dopamine receptor binding
A0031821molecular_functionG protein-coupled serotonin receptor binding
A0043434biological_processresponse to peptide hormone
A0043949biological_processregulation of cAMP-mediated signaling
A0046872molecular_functionmetal ion binding
A0051301biological_processcell division
A0060236biological_processregulation of mitotic spindle organization
A0070062cellular_componentextracellular exosome
A0072678biological_processT cell migration
A1904322biological_processcellular response to forskolin
A1904778biological_processpositive regulation of protein localization to cell cortex
B0001750cellular_componentphotoreceptor outer segment
B0001917cellular_componentphotoreceptor inner segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0008283biological_processcell population proliferation
B0010659biological_processcardiac muscle cell apoptotic process
B0030159molecular_functionsignaling receptor complex adaptor activity
B0030425cellular_componentdendrite
B0030507molecular_functionspectrin binding
B0042622cellular_componentphotoreceptor outer segment membrane
B0044297cellular_componentcell body
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0047391molecular_functionalkylglycerophosphoethanolamine phosphodiesterase activity
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0071456biological_processcellular response to hypoxia
C0005515molecular_functionprotein binding
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0016020cellular_componentmembrane
C0031681molecular_functionG-protein beta-subunit binding
C0048144biological_processfibroblast proliferation
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
F0000287molecular_functionmagnesium ion binding
F0001664molecular_functionG protein-coupled receptor binding
F0003924molecular_functionGTPase activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0005765cellular_componentlysosomal membrane
F0005813cellular_componentcentrosome
F0005834cellular_componentheterotrimeric G-protein complex
F0005856cellular_componentcytoskeleton
F0005886cellular_componentplasma membrane
F0005938cellular_componentcell cortex
F0007165biological_processsignal transduction
F0007186biological_processG protein-coupled receptor signaling pathway
F0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
F0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
F0016020cellular_componentmembrane
F0019001molecular_functionguanyl nucleotide binding
F0019003molecular_functionGDP binding
F0030496cellular_componentmidbody
F0031683molecular_functionG-protein beta/gamma-subunit complex binding
F0031749molecular_functionD2 dopamine receptor binding
F0031821molecular_functionG protein-coupled serotonin receptor binding
F0043434biological_processresponse to peptide hormone
F0043949biological_processregulation of cAMP-mediated signaling
F0046872molecular_functionmetal ion binding
F0051301biological_processcell division
F0060236biological_processregulation of mitotic spindle organization
F0070062cellular_componentextracellular exosome
F0072678biological_processT cell migration
F1904322biological_processcellular response to forskolin
F1904778biological_processpositive regulation of protein localization to cell cortex
M0001965molecular_functionG-protein alpha-subunit binding
M0004930molecular_functionG protein-coupled receptor activity
M0004979molecular_functionbeta-endorphin receptor activity
M0004985molecular_functionG protein-coupled opioid receptor activity
M0005245molecular_functionvoltage-gated calcium channel activity
M0005515molecular_functionprotein binding
M0005737cellular_componentcytoplasm
M0005768cellular_componentendosome
M0005783cellular_componentendoplasmic reticulum
M0005794cellular_componentGolgi apparatus
M0005886cellular_componentplasma membrane
M0007186biological_processG protein-coupled receptor signaling pathway
M0007187biological_processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
M0007197biological_processadenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
M0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
M0007218biological_processneuropeptide signaling pathway
M0007600biological_processsensory perception
M0008285biological_processnegative regulation of cell population proliferation
M0016020cellular_componentmembrane
M0019233biological_processsensory perception of pain
M0030424cellular_componentaxon
M0030425cellular_componentdendrite
M0031681molecular_functionG-protein beta-subunit binding
M0038003biological_processG protein-coupled opioid receptor signaling pathway
M0038047molecular_functionmorphine receptor activity
M0042923molecular_functionneuropeptide binding
M0042995cellular_componentcell projection
M0043005cellular_componentneuron projection
M0043204cellular_componentperikaryon
M0045202cellular_componentsynapse
M0048149biological_processbehavioral response to ethanol
M0050769biological_processpositive regulation of neurogenesis
M0061358biological_processnegative regulation of Wnt protein secretion
M0070374biological_processpositive regulation of ERK1 and ERK2 cascade
M0070588biological_processcalcium ion transmembrane transport
M0071315biological_processcellular response to morphine
M0080135biological_processregulation of cellular response to stress
M2000310biological_processregulation of NMDA receptor activity
R0001965molecular_functionG-protein alpha-subunit binding
R0004930molecular_functionG protein-coupled receptor activity
R0004979molecular_functionbeta-endorphin receptor activity
R0004985molecular_functionG protein-coupled opioid receptor activity
R0005245molecular_functionvoltage-gated calcium channel activity
R0005515molecular_functionprotein binding
R0005737cellular_componentcytoplasm
R0005768cellular_componentendosome
R0005783cellular_componentendoplasmic reticulum
R0005794cellular_componentGolgi apparatus
R0005886cellular_componentplasma membrane
R0007186biological_processG protein-coupled receptor signaling pathway
R0007187biological_processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
R0007197biological_processadenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
R0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
R0007218biological_processneuropeptide signaling pathway
R0007600biological_processsensory perception
R0008285biological_processnegative regulation of cell population proliferation
R0016020cellular_componentmembrane
R0019233biological_processsensory perception of pain
R0030424cellular_componentaxon
R0030425cellular_componentdendrite
R0031681molecular_functionG-protein beta-subunit binding
R0038003biological_processG protein-coupled opioid receptor signaling pathway
R0038047molecular_functionmorphine receptor activity
R0042923molecular_functionneuropeptide binding
R0042995cellular_componentcell projection
R0043005cellular_componentneuron projection
R0043204cellular_componentperikaryon
R0045202cellular_componentsynapse
R0048149biological_processbehavioral response to ethanol
R0050769biological_processpositive regulation of neurogenesis
R0061358biological_processnegative regulation of Wnt protein secretion
R0070374biological_processpositive regulation of ERK1 and ERK2 cascade
R0070588biological_processcalcium ion transmembrane transport
R0071315biological_processcellular response to morphine
R0080135biological_processregulation of cellular response to stress
R2000310biological_processregulation of NMDA receptor activity
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSIfTLCTMSVDRYIaV
ChainResidueDetails
RTHR155-VAL171

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
CALA2
AASN269
FGLU43
FASN269

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
CCYS68
ATHR181
FSER47
FTHR181
MASP166-ASN185
MLEU256-ARG279

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
CCYS68
FSER151

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
ChainResidueDetails
ALEU175
FLEU175
RLEU307-THR314
MMET132-CYS142
MALA208-TRP230
MLEU307-THR314

site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:21115486
ChainResidueDetails
AASP200
FASP200

site_idSWS_FT_FI6
Number of Residues2
DetailsBINDING: BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
ChainResidueDetails
ASER326
FSER326

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250
ChainResidueDetails
AARG178
FARG178

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
ChainResidueDetails
AGLN204
FGLN204

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: ADP-ribosylcysteine; by pertussis toxin => ECO:0000250
ChainResidueDetails
ACYS351
FCYS351

site_idSWS_FT_FI10
Number of Residues2
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:20213681, ECO:0000269|PubMed:25255805
ChainResidueDetails
AGLY2
FGLY2

site_idSWS_FT_FI11
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P10824
ChainResidueDetails
ACYS3
FCYS3

site_idSWS_FT_FI12
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000255
ChainResidueDetails
RCYS353
MCYS353

site_idSWS_FT_FI13
Number of Residues10
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN9
MASN48
RASN12
RASN33
RASN40
RASN48
MASN9
MASN12
MASN33
MASN40

222624

PDB entries from 2024-07-17

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