8EFJ
A structural study of selectivity mechanisms for JNK3 and p38 alpha with indazole scaffold probing compounds
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Mitogen-activated protein kinase 14 | polymer | 367 | 42238.1 | 1 | UniProt (P47811) Pfam (PF00069) In PDB | Mus musculus (house mouse) | MAP kinase 14,MAPK 14,CRK1,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha |
2 | A | octyl beta-D-glucopyranoside | non-polymer | 292.4 | 2 | Chemie (BOG) | |||
3 | A | (4P)-4-[5-(2-chloro-6-fluoroanilino)-6-(methoxymethyl)-1H-indazol-1-yl]-N-methylthiophene-2-carboxamide | non-polymer | 444.9 | 1 | Chemie (WHQ) | |||
4 | water | water | 18.0 | 200 | Chemie (HOH) |
Sequence modifications
A: 2 - 360 (UniProt: P47811)
PDB | External Database | Details |
---|---|---|
Met -6 | - | initiating methionine |
Ala -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
His 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 42238.1 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1029.6 | |
All* | Total formula weight | 43267.8 |