8EFH

Helical reconstruction of the human cardiac actin-tropomyosin-myosin complex in complex with ADP-Mg2+

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	beta-cardiac myosin II	polymer	865	99157.7	1	UniProt (P12883) Pfam (PF02736) Pfam (PF00063) In PDB	Homo sapiens (human)	Myosin heavy chain 7,Myosin heavy chain slow isoform,MyHC-slow,Myosin heavy chain,cardiac muscle beta isoform,MyHC-beta
2	F, B, C, D, E	Actin, alpha cardiac muscle 1	polymer	377	42064.9	5	UniProt (B6VNT8) Pfam (PF00022) UniProt (by SIFTS) (P68137) In PDB	Sus scrofa (pig)	Cardiac muscle alpha actin 1
3	O, P	Tropomyosin alpha-1 chain	polymer	284	32763.6	2	UniProt (P09493) Pfam (PF00261) In PDB	Homo sapiens (human)	Alpha-tropomyosin,Tropomyosin-1
4	A, F, B, C, D...	MAGNESIUM ION	non-polymer		24.3	6	Chemie (MG)
5	A, F, B, C, D...	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	6	Chemie (ADP)

Sequence modifications

A: 1 - 842 (UniProt: P12883)

PDB	External Database	Details
Gly 843	-	expression tag
Leu 844	-	expression tag
Asn 845	-	expression tag
Asp 846	-	expression tag
Ile 847	-	expression tag
Phe 848	-	expression tag
Glu 849	-	expression tag
Ala 850	-	expression tag
Gln 851	-	expression tag
Lys 852	-	expression tag
Ile 853	-	expression tag
Glu 854	-	expression tag
Trp 855	-	expression tag
His 856	-	expression tag
Glu 857	-	expression tag
Asp 858	-	expression tag
Tyr 859	-	expression tag
Lys 860	-	expression tag
Asp 861	-	expression tag
Asp 862	-	expression tag
Asp 863	-	expression tag
Asp 864	-	expression tag
Lys 865	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	375009.4
Non-Polymers*	Number of molecules	12
	Total formula weight	2709.0
All*	Total formula weight	377718.4

*Water molecules are not included.