8EBX
XPA repositioning Core7 of TFIIH relative to XPC-DNA lesion (AP)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | TFIIH basal transcription factor complex helicase XPB subunit | polymer | 782 | 89404.7 | 1 | UniProt (P19447) Pfam (PF13625) Pfam (PF04851) Pfam (PF16203) In PDB | Homo sapiens (human) | Basic transcription factor 2 89 kDa subunit, BTF2 p89, DNA excision repair protein ERCC-3, DNA repair protein complementing XP-B cells, TFIIH basal transcription factor complex 89 kDa subunit, TFIIH p89, Xeroderma pigmentosum group B-complementing protein |
| 2 | B | General transcription and DNA repair factor IIH helicase subunit XPD | polymer | 768 | 88018.0 | 1 | UniProt (P18074) Pfam (PF06733) Pfam (PF06777) Pfam (PF13307) In PDB | Homo sapiens (human) | TFIIH subunit XPD,Basic transcription factor 2 80 kDa subunit,BTF2 p80,CXPD,DNA excision repair protein ERCC-2,DNA repair protein complementing XP-D cells,TFIIH basal transcription factor complex 80 kDa subunit,TFIIH 80 kDa subunit,TFIIH p80,Xeroderma pigmentosum group D-complementing protein |
| 3 | C | General transcription factor IIH subunit 1 | polymer | 548 | 62116.5 | 1 | UniProt (P32780) Pfam (PF08567) Pfam (PF03909) In PDB | Homo sapiens (human) | Basic transcription factor 2 62 kDa subunit,BTF2 p62,General transcription factor IIH polypeptide 1,TFIIH basal transcription factor complex p62 subunit |
| 4 | D | General transcription factor IIH subunit 4, p52 | polymer | 462 | 52245.2 | 1 | UniProt (Q92759) Pfam (PF18307) Pfam (PF03849) In PDB | Homo sapiens (human) | Basic transcription factor 2 52 kDa subunit, BTF2 p52, General transcription factor IIH polypeptide 4, TFIIH basal transcription factor complex p52 subunit |
| 5 | E | General transcription factor IIH subunit 2 | polymer | 417 | 46926.6 | 1 | UniProt (Q13888) Pfam (PF04056) Pfam (PF07975) In PDB | Homo sapiens (human) | Basic transcription factor 2 44 kDa subunit,BTF2 p44,General transcription factor IIH polypeptide 2,TFIIH basal transcription factor complex p44 subunit |
| 6 | F | General transcription factor IIH subunit 3 | polymer | 308 | 34416.0 | 1 | UniProt (Q13889) Pfam (PF03850) In PDB | Homo sapiens (human) | p34, Basic transcription factor 2 44 kDa subunit, BTF2 p44, General transcription factor IIH polypeptide 2, TFIIH basal transcription factor complex p44 subunit |
| 7 | G | General transcription factor IIH subunit 5 | polymer | 71 | 8060.4 | 1 | UniProt (Q6ZYL4) Pfam (PF06331) In PDB | Homo sapiens (human) | General transcription factor IIH polypeptide 5, TFB5 ortholog, TFIIH basal transcription factor complex TTD-A subunit |
| 8 | H | Xeroderma pigmentosum, complementation group C, isoform CRA_a | polymer | 950 | 107437.6 | 1 | UniProt (A0A024R2M8) Pfam (PF03835) Pfam (PF10403) Pfam (PF10404) Pfam (PF10405) UniProt (by SIFTS) (Q01831) In PDB | Homo sapiens (human) | |
| 9 | J | Centrin-2 | polymer | 172 | 19769.5 | 1 | UniProt (P41208) Pfam (PF13499) In PDB | Homo sapiens (human) | Caltractin isoform 1 |
| 10 | K | DNA repair protein complementing XP-A cells | polymer | 273 | 31422.1 | 1 | UniProt (P23025) Pfam (PF01286) Pfam (PF05181) In PDB | Homo sapiens (human) | Xeroderma pigmentosum group A-complementing protein |
| 11 | L | DNA (Ap) | polymer | 40 | 12175.8 | 1 | synthetic construct | ||
| 12 | M | DNA | polymer | 40 | 12183.8 | 1 | synthetic construct | ||
| 13 | B | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 1 | Chemie (SF4) | |||
| 14 | E, F, K | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 15 | J | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) |
Sequence modifications
B: 1 - 760 (UniProt: P18074)
E: 1 - 395 (UniProt: Q13888)
H: 1 - 940 (UniProt: A0A024R2M8)
| PDB | External Database | Details |
|---|---|---|
| Asp 761 | - | expression tag |
| Tyr 762 | - | expression tag |
| Lys 763 | - | expression tag |
| Asp 764 | - | expression tag |
| Asp 765 | - | expression tag |
| Asp 766 | - | expression tag |
| Asp 767 | - | expression tag |
| Lys 768 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -21 | - | initiating methionine |
| Gly -20 | - | expression tag |
| Ser -19 | - | expression tag |
| Ser -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Leu -8 | - | expression tag |
| Glu -7 | - | expression tag |
| Val -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Phe -4 | - | expression tag |
| Gln -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| His 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -9 | - | initiating methionine |
| Asp -8 | - | expression tag |
| Tyr -7 | - | expression tag |
| Lys -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Lys -1 | - | expression tag |
| His 0 | - | expression tag |
| Val 499 | Ala 499 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 564176.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 824.3 | |
| All* | Total formula weight | 565000.5 |
