8EBX

XPA repositioning Core7 of TFIIH relative to XPC-DNA lesion (AP)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000112	cellular_component	nucleotide-excision repair factor 3 complex
A	0000439	cellular_component	transcription factor TFIIH core complex
A	0000717	biological_process	nucleotide-excision repair, DNA duplex unwinding
A	0001666	biological_process	response to hypoxia
A	0003677	molecular_function	DNA binding
A	0003678	molecular_function	DNA helicase activity
A	0003684	molecular_function	damaged DNA binding
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005669	cellular_component	transcription factor TFIID complex
A	0005675	cellular_component	transcription factor TFIIH holo complex
A	0006265	biological_process	DNA topological change
A	0006281	biological_process	DNA repair
A	0006283	biological_process	transcription-coupled nucleotide-excision repair
A	0006289	biological_process	nucleotide-excision repair
A	0006366	biological_process	transcription by RNA polymerase II
A	0006367	biological_process	transcription initiation at RNA polymerase II promoter
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0006915	biological_process	apoptotic process
A	0006979	biological_process	response to oxidative stress
A	0008104	biological_process	protein localization
A	0009411	biological_process	response to UV
A	0009650	biological_process	UV protection
A	0016787	molecular_function	hydrolase activity
A	0016853	molecular_function	isomerase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0035315	biological_process	hair cell differentiation
A	0043065	biological_process	positive regulation of apoptotic process
A	0043138	molecular_function	3'-5' DNA helicase activity
A	0048568	biological_process	embryonic organ development
A	0097550	cellular_component	transcription preinitiation complex
A	0140640	molecular_function	catalytic activity, acting on a nucleic acid
A	1901990	biological_process	regulation of mitotic cell cycle phase transition
A	1990841	molecular_function	promoter-specific chromatin binding
B	0000439	cellular_component	transcription factor TFIIH core complex
B	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B	0001666	biological_process	response to hypoxia
B	0001701	biological_process	in utero embryonic development
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003678	molecular_function	DNA helicase activity
B	0003684	molecular_function	damaged DNA binding
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005669	cellular_component	transcription factor TFIID complex
B	0005675	cellular_component	transcription factor TFIIH holo complex
B	0005737	cellular_component	cytoplasm
B	0005819	cellular_component	spindle
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006259	biological_process	DNA metabolic process
B	0006281	biological_process	DNA repair
B	0006283	biological_process	transcription-coupled nucleotide-excision repair
B	0006289	biological_process	nucleotide-excision repair
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006362	biological_process	transcription elongation by RNA polymerase I
B	0006366	biological_process	transcription by RNA polymerase II
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0006915	biological_process	apoptotic process
B	0006974	biological_process	DNA damage response
B	0006979	biological_process	response to oxidative stress
B	0007059	biological_process	chromosome segregation
B	0008340	biological_process	determination of adult lifespan
B	0009411	biological_process	response to UV
B	0009650	biological_process	UV protection
B	0009791	biological_process	post-embryonic development
B	0016787	molecular_function	hydrolase activity
B	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
B	0016887	molecular_function	ATP hydrolysis activity
B	0021510	biological_process	spinal cord development
B	0022405	biological_process	hair cycle process
B	0030198	biological_process	extracellular matrix organization
B	0030282	biological_process	bone mineralization
B	0030674	molecular_function	protein-macromolecule adaptor activity
B	0032289	biological_process	central nervous system myelin formation
B	0032508	biological_process	DNA duplex unwinding
B	0035264	biological_process	multicellular organism growth
B	0035315	biological_process	hair cell differentiation
B	0040016	biological_process	embryonic cleavage
B	0042274	biological_process	ribosomal small subunit biogenesis
B	0043139	molecular_function	5'-3' DNA helicase activity
B	0043249	biological_process	erythrocyte maturation
B	0043588	biological_process	skin development
B	0045951	biological_process	positive regulation of mitotic recombination
B	0046872	molecular_function	metal ion binding
B	0048009	biological_process	insulin-like growth factor receptor signaling pathway
B	0048568	biological_process	embryonic organ development
B	0048820	biological_process	hair follicle maturation
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B	0060218	biological_process	hematopoietic stem cell differentiation
B	0070516	cellular_component	CAK-ERCC2 complex
B	0071425	biological_process	hematopoietic stem cell proliferation
B	0071817	cellular_component	MMXD complex
B	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
B	1901990	biological_process	regulation of mitotic cell cycle phase transition
C	0000079	biological_process	regulation of cyclin-dependent protein serine/threonine kinase activity
C	0000439	cellular_component	transcription factor TFIIH core complex
C	0003682	molecular_function	chromatin binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005675	cellular_component	transcription factor TFIIH holo complex
C	0006281	biological_process	DNA repair
C	0006289	biological_process	nucleotide-excision repair
C	0006351	biological_process	DNA-templated transcription
C	0006360	biological_process	transcription by RNA polymerase I
C	0006366	biological_process	transcription by RNA polymerase II
C	0006367	biological_process	transcription initiation at RNA polymerase II promoter
C	0009755	biological_process	hormone-mediated signaling pathway
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0046966	molecular_function	nuclear thyroid hormone receptor binding
D	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
D	0000439	cellular_component	transcription factor TFIIH core complex
D	0001671	molecular_function	ATPase activator activity
D	0003690	molecular_function	double-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005669	cellular_component	transcription factor TFIID complex
D	0005675	cellular_component	transcription factor TFIIH holo complex
D	0006281	biological_process	DNA repair
D	0006289	biological_process	nucleotide-excision repair
D	0006366	biological_process	transcription by RNA polymerase II
D	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
D	0016607	cellular_component	nuclear speck
E	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
E	0000439	cellular_component	transcription factor TFIIH core complex
E	0002031	biological_process	G protein-coupled receptor internalization
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005669	cellular_component	transcription factor TFIID complex
E	0005675	cellular_component	transcription factor TFIIH holo complex
E	0006281	biological_process	DNA repair
E	0006289	biological_process	nucleotide-excision repair
E	0006351	biological_process	DNA-templated transcription
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0006366	biological_process	transcription by RNA polymerase II
E	0006367	biological_process	transcription initiation at RNA polymerase II promoter
E	0008270	molecular_function	zinc ion binding
E	0009411	biological_process	response to UV
E	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
E	0016607	cellular_component	nuclear speck
E	0046872	molecular_function	metal ion binding
F	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
F	0000439	cellular_component	transcription factor TFIIH core complex
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005669	cellular_component	transcription factor TFIID complex
F	0005675	cellular_component	transcription factor TFIIH holo complex
F	0006281	biological_process	DNA repair
F	0006289	biological_process	nucleotide-excision repair
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006366	biological_process	transcription by RNA polymerase II
F	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
F	0046872	molecular_function	metal ion binding
F	0097550	cellular_component	transcription preinitiation complex
G	0000439	cellular_component	transcription factor TFIIH core complex
G	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005669	cellular_component	transcription factor TFIID complex
G	0005675	cellular_component	transcription factor TFIIH holo complex
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0006281	biological_process	DNA repair
G	0006289	biological_process	nucleotide-excision repair
G	0006294	biological_process	nucleotide-excision repair, preincision complex assembly
G	0006362	biological_process	transcription elongation by RNA polymerase I
G	0006366	biological_process	transcription by RNA polymerase II
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0071480	biological_process	cellular response to gamma radiation
H	0000109	cellular_component	nucleotide-excision repair complex
H	0000111	cellular_component	nucleotide-excision repair factor 2 complex
H	0000404	molecular_function	heteroduplex DNA loop binding
H	0000405	molecular_function	bubble DNA binding
H	0000720	biological_process	pyrimidine dimer repair by nucleotide-excision repair
H	0000785	cellular_component	chromatin
H	0003677	molecular_function	DNA binding
H	0003684	molecular_function	damaged DNA binding
H	0003697	molecular_function	single-stranded DNA binding
H	0003713	molecular_function	transcription coactivator activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005730	cellular_component	nucleolus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006281	biological_process	DNA repair
H	0006289	biological_process	nucleotide-excision repair
H	0006298	biological_process	mismatch repair
H	0006974	biological_process	DNA damage response
H	0009410	biological_process	response to xenobiotic stimulus
H	0010224	biological_process	response to UV-B
H	0010996	biological_process	response to auditory stimulus
H	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
H	0043231	cellular_component	intracellular membrane-bounded organelle
H	0044877	molecular_function	protein-containing complex binding
H	0045893	biological_process	positive regulation of DNA-templated transcription
H	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
H	0070914	biological_process	UV-damage excision repair
H	0071942	cellular_component	XPC complex
H	0090734	cellular_component	site of DNA damage
H	0140612	molecular_function	DNA damage sensor activity
H	1901990	biological_process	regulation of mitotic cell cycle phase transition
J	0000278	biological_process	mitotic cell cycle
J	0005509	molecular_function	calcium ion binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005635	cellular_component	nuclear envelope
J	0005643	cellular_component	nuclear pore
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005813	cellular_component	centrosome
J	0005814	cellular_component	centriole
J	0005815	cellular_component	microtubule organizing center
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0005929	cellular_component	cilium
J	0006281	biological_process	DNA repair
J	0006289	biological_process	nucleotide-excision repair
J	0007099	biological_process	centriole replication
J	0007283	biological_process	spermatogenesis
J	0008017	molecular_function	microtubule binding
J	0015031	biological_process	protein transport
J	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
J	0032391	cellular_component	photoreceptor connecting cilium
J	0032465	biological_process	regulation of cytokinesis
J	0032795	molecular_function	heterotrimeric G-protein binding
J	0036064	cellular_component	ciliary basal body
J	0044615	cellular_component	nuclear pore nuclear basket
J	0045177	cellular_component	apical part of cell
J	0046872	molecular_function	metal ion binding
J	0051028	biological_process	mRNA transport
J	0051301	biological_process	cell division
J	0070390	cellular_component	transcription export complex 2
J	0071942	cellular_component	XPC complex
J	0097729	cellular_component	9+2 motile cilium
K	0000110	cellular_component	nucleotide-excision repair factor 1 complex
K	0000715	biological_process	nucleotide-excision repair, DNA damage recognition
K	0003677	molecular_function	DNA binding
K	0003684	molecular_function	damaged DNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005662	cellular_component	DNA replication factor A complex
K	0006281	biological_process	DNA repair
K	0006284	biological_process	base-excision repair
K	0006289	biological_process	nucleotide-excision repair
K	0009650	biological_process	UV protection
K	0010996	biological_process	response to auditory stimulus
K	0019904	molecular_function	protein domain specific binding
K	0034504	biological_process	protein localization to nucleus
K	0042803	molecular_function	protein homodimerization activity
K	0045171	cellular_component	intercellular bridge
K	0046872	molecular_function	metal ion binding
K	0070914	biological_process	UV-damage excision repair
K	1901255	biological_process	nucleotide-excision repair involved in interstrand cross-link repair
K	1990837	molecular_function	sequence-specific double-stranded DNA binding

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DADGTGTIDvkEL

Chain	Residue	Details
J	ASP41-LEU53
J	ASP150-PHE162

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site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cav..CqnvFcvdcdvfvHdsl..H

Chain	Residue	Details
E	CYS360-HIS380

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site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. MIDEADRdG

Chain	Residue	Details
J	MET145-GLY153

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site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AvVVFDEAHN

Chain	Residue	Details
B	ALA229-ASN238

---

site_id	PS00752
Number of Residues	25
Details	XPA_1 XPA protein signature 1. CeECgkeFm.DsyLmnhFdlptCdnC

Chain	Residue	Details
K	CYS105-CYS129

---

site_id	PS00753
Number of Residues	17
Details	XPA_2 XPA protein signature 2. LITKTEaKqEYLLkDcD

Chain	Residue	Details
K	LEU138-ASP154

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569

Chain	Residue	Details
H	SER94
J	GLU161
J	ASP43
J	THR45
J	THR47
J	GLU52
J	ASP150
J	ASP152
J	ASP154
J	GLU156

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231

Chain	Residue	Details
H	SER129
C	SER357
B	CYS155

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
H	SER140
H	SER397
H	SER398
H	SER399
H	SER453
H	SER460
H	SER903

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
H	THR169
K	LYS86

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
H	THR876
K	LYS145

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
H	SER883
H	SER884

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
H	SER891

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
H	LYS41
H	LYS89
H	LYS161

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733

Chain	Residue	Details
H	LYS81

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