8EBT
XPA repositioning Core7 of TFIIH relative to XPC-DNA lesion (Cy5)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | General transcription and DNA repair factor IIH helicase subunit XPB | polymer | 603 | 69405.0 | 1 | Pfam (PF13625) Pfam (PF04851) Pfam (PF16203) UniProt (by SIFTS) (P19447) | Homo sapiens | |
| 2 | B (B) | General transcription and DNA repair factor IIH helicase subunit XPD | polymer | 730 | 83582.3 | 1 | UniProt (P18074) Pfam (PF06733) Pfam (PF06777) Pfam (PF13307) | Homo sapiens (human) | TFIIH subunit XPD,Basic transcription factor 2 80 kDa subunit,BTF2 p80,CXPD,DNA excision repair protein ERCC-2,DNA repair protein complementing XP-D cells,TFIIH basal transcription factor complex 80 kDa subunit,TFIIH 80 kDa subunit,TFIIH p80,Xeroderma pigmentosum group D-complementing protein |
| 3 | C (C) | General transcription factor IIH subunit 1 | polymer | 438 | 49569.9 | 1 | UniProt (P32780) Pfam (PF03909) | Homo sapiens (human) | Basic transcription factor 2 62 kDa subunit,BTF2 p62,General transcription factor IIH polypeptide 1,TFIIH basal transcription factor complex p62 subunit |
| 4 | D (D) | General transcription factor IIH subunit 4 | polymer | 446 | 50432.1 | 1 | UniProt (Q92759) Pfam (PF03849) Pfam (PF18307) | Homo sapiens (human) | Basic transcription factor 2 52 kDa subunit,BTF2 p52,General transcription factor IIH polypeptide 4,TFIIH basal transcription factor complex p52 subunit |
| 5 | E (E) | General transcription factor IIH subunit 2 | polymer | 380 | 42772.1 | 1 | UniProt (Q13888) Pfam (PF04056) Pfam (PF07975) | Homo sapiens (human) | Basic transcription factor 2 44 kDa subunit,BTF2 p44,General transcription factor IIH polypeptide 2,TFIIH basal transcription factor complex p44 subunit |
| 6 | F (F) | General transcription factor IIH subunit 3 | polymer | 284 | 31788.7 | 1 | UniProt (Q13889) Pfam (PF03850) | Homo sapiens (human) | Basic transcription factor 2 34 kDa subunit,BTF2 p34,General transcription factor IIH polypeptide 3,TFIIH basal transcription factor complex p34 subunit |
| 7 | G (G) | General transcription factor IIH subunit 5 | polymer | 66 | 7458.6 | 1 | UniProt (Q6ZYL4) Pfam (PF06331) | Homo sapiens (human) | General transcription factor IIH polypeptide 5,TFB5 ortholog,TFIIH basal transcription factor complex TTD-A subunit,TFIIH subunit p8 |
| 8 | H (H) | DNA repair protein complementing XP-C cells | polymer | 274 | 31552.3 | 1 | Pfam (PF10403) Pfam (PF10404) Pfam (PF10405) UniProt (by SIFTS) (Q01831) | Homo sapiens | |
| 9 | I (J) | Centrin-2 | polymer | 70 | 8183.1 | 1 | UniProt (P41208) Pfam (PF13499) | Homo sapiens (human) | Caltractin isoform 1 |
| 10 | J (K) | DNA repair protein complementing XP-A cells | polymer | 172 | 20787.9 | 1 | UniProt (P23025) Pfam (PF01286) Pfam (PF05181) | Homo sapiens (human) | Xeroderma pigmentosum group A-complementing protein |
| 11 | K (L) | DNA (Cy5) | polymer | 44 | 13914.2 | 1 | synthetic construct | ||
| 12 | L (M) | DNA | polymer | 45 | 13707.8 | 1 | synthetic construct | ||
| 13 | M (B) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 1 | Chemie (SF4) | |||
| 14 | N, O, P, Q, R... (E, F, K) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 15 | S, T (J) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) |
Sequence modifications
E: 8 - 387 (UniProt: Q13888)
| PDB | External Database | Details |
|---|---|---|
| Gly 52 | Gln 52 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 423154.1 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 824.3 | |
| All* | Total formula weight | 423978.4 |
