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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8EBT

XPA repositioning Core7 of TFIIH relative to XPC-DNA lesion (Cy5)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003678molecular_functionDNA helicase activity
A0005524molecular_functionATP binding
A0006289biological_processnucleotide-excision repair
A0006367biological_processtranscription initiation at RNA polymerase II promoter
A0016787molecular_functionhydrolase activity
B0000439cellular_componenttranscription factor TFIIH core complex
B0003676molecular_functionnucleic acid binding
B0003677molecular_functionDNA binding
B0003678molecular_functionDNA helicase activity
B0003684molecular_functiondamaged DNA binding
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005669cellular_componenttranscription factor TFIID complex
B0005675cellular_componenttranscription factor TFIIH holo complex
B0005737cellular_componentcytoplasm
B0005819cellular_componentspindle
B0006139biological_processnucleobase-containing compound metabolic process
B0006283biological_processtranscription-coupled nucleotide-excision repair
B0006289biological_processnucleotide-excision repair
B0006351biological_processDNA-templated transcription
B0006357biological_processregulation of transcription by RNA polymerase II
B0006366biological_processtranscription by RNA polymerase II
B0006367biological_processtranscription initiation at RNA polymerase II promoter
B0006915biological_processapoptotic process
B0006979biological_processresponse to oxidative stress
B0007059biological_processchromosome segregation
B0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
B0016887molecular_functionATP hydrolysis activity
B0030674molecular_functionprotein-macromolecule adaptor activity
B0035315biological_processhair cell differentiation
B0043139molecular_function5'-3' DNA helicase activity
B0045951biological_processpositive regulation of mitotic recombination
B0070516cellular_componentCAK-ERCC2 complex
B0071817cellular_componentMMXD complex
B1901990biological_processregulation of mitotic cell cycle phase transition
C0000439cellular_componenttranscription factor TFIIH core complex
C0006289biological_processnucleotide-excision repair
C0006351biological_processDNA-templated transcription
D0000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
D0000439cellular_componenttranscription factor TFIIH core complex
D0001671molecular_functionATPase activator activity
D0003690molecular_functiondouble-stranded DNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005669cellular_componenttranscription factor TFIID complex
D0005675cellular_componenttranscription factor TFIIH holo complex
D0006281biological_processDNA repair
D0006289biological_processnucleotide-excision repair
D0006366biological_processtranscription by RNA polymerase II
D0006367biological_processtranscription initiation at RNA polymerase II promoter
D0016251molecular_functionRNA polymerase II general transcription initiation factor activity
D0016607cellular_componentnuclear speck
E0000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
E0000439cellular_componenttranscription factor TFIIH core complex
E0002031biological_processG protein-coupled receptor internalization
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005669cellular_componenttranscription factor TFIID complex
E0005675cellular_componenttranscription factor TFIIH holo complex
E0006281biological_processDNA repair
E0006289biological_processnucleotide-excision repair
E0006351biological_processDNA-templated transcription
E0006357biological_processregulation of transcription by RNA polymerase II
E0006366biological_processtranscription by RNA polymerase II
E0006367biological_processtranscription initiation at RNA polymerase II promoter
E0008270molecular_functionzinc ion binding
E0009411biological_processresponse to UV
E0016251molecular_functionRNA polymerase II general transcription initiation factor activity
E0016607cellular_componentnuclear speck
F0000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
F0000439cellular_componenttranscription factor TFIIH core complex
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005669cellular_componenttranscription factor TFIID complex
F0005675cellular_componenttranscription factor TFIIH holo complex
F0006281biological_processDNA repair
F0006289biological_processnucleotide-excision repair
F0006355biological_processregulation of DNA-templated transcription
F0006366biological_processtranscription by RNA polymerase II
F0006367biological_processtranscription initiation at RNA polymerase II promoter
F0016251molecular_functionRNA polymerase II general transcription initiation factor activity
F0097550cellular_componenttranscription preinitiation complex
G0000439cellular_componenttranscription factor TFIIH core complex
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005669cellular_componenttranscription factor TFIID complex
G0005675cellular_componenttranscription factor TFIIH holo complex
G0005730cellular_componentnucleolus
G0005737cellular_componentcytoplasm
G0006289biological_processnucleotide-excision repair
G0006294biological_processnucleotide-excision repair, preincision complex assembly
G0006366biological_processtranscription by RNA polymerase II
G0006367biological_processtranscription initiation at RNA polymerase II promoter
H0003677molecular_functionDNA binding
H0003684molecular_functiondamaged DNA binding
H0005634cellular_componentnucleus
H0006289biological_processnucleotide-excision repair
J0005509molecular_functioncalcium ion binding
K0003684molecular_functiondamaged DNA binding
K0006289biological_processnucleotide-excision repair
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DRDGDGEVSeqEF
ChainResidueDetails
JASP150-PHE162
site_idPS00028
Number of Residues21
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cav..CqnvFcvdcdvfvHdsl..H
ChainResidueDetails
ECYS360-HIS380
site_idPS00039
Number of Residues9
DetailsDEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. MIDEADRdG
ChainResidueDetails
JMET145-GLY153
site_idPS00690
Number of Residues10
DetailsDEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AvVVFDEAHN
ChainResidueDetails
BALA229-ASN238
site_idPS00752
Number of Residues25
DetailsXPA_1 XPA protein signature 1. CeECgkeFm.DsyLmnhFdlptCdnC
ChainResidueDetails
KCYS105-CYS129
site_idPS00753
Number of Residues17
DetailsXPA_2 XPA protein signature 2. LITKTEaKqEYLLkDcD
ChainResidueDetails
KLEU138-ASP154
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues161
DetailsDomain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues3
DetailsMotif: {"description":"DEVH box"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues199
DetailsRegion: {"description":"Mediates interaction with MMS19"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues3
DetailsMotif: {"description":"DEAH box"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues13
DetailsMotif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31253769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RO4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues176
DetailsDomain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues34
DetailsZinc finger: {"description":"C4-type"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"A0JN27","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues64
DetailsRegion: {"description":"DNA-binding; preference for single stranded DNA; required for formation of stable nucleoprotein complex"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues19
DetailsRegion: {"description":"Interaction with CETN2"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues35
DetailsDomain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues24
DetailsZinc finger: {"evidences":[{"source":"PubMed","id":"2234061","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31253769","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31253769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1D4U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XPA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RO4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16540648","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

251174

PDB entries from 2026-03-25

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