8EAB
NKG2D complexed with inhibitor 4f
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NKG2-D type II integral membrane protein | polymer | 129 | 14880.8 | 2 | UniProt (P26718) Pfam (PF00059) | Homo sapiens (human) | Killer cell lectin-like receptor subfamily K member 1,NK cell receptor D,NKG2-D-activating NK receptor |
| 2 | C, E (B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 3 | D (B) | N-[(1S)-2-oxo-1-[3-(trifluoromethyl)phenyl]-2-({4-[4-(trifluoromethyl)phenyl]pyridin-3-yl}amino)ethyl]-4-[4-(trifluoromethyl)phenyl]pyridine-3-carboxamide | non-polymer | 688.5 | 1 | Chemie (VN2) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 192 | Chemie (HOH) |
Sequence modifications
A, B: 90 - 216 (UniProt: P26718)
| PDB | External Database | Details |
|---|---|---|
| Met 88 | - | initiating methionine |
| Gly 89 | - | expression tag |
| Glu 117 | Ser 117 | engineered mutation |
| Ser 173 | Ile 173 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29761.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 900.8 | |
| All* | Total formula weight | 30662.4 |
