8E94

PYD-106-bound Human GluN1a-GluN2C NMDA receptor in intact conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Glutamate receptor ionotropic, NMDA 1	polymer	847	95081.7	2	UniProt (Q05586) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060)	Homo sapiens (human)	GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1
2	B, D (B, D)	Glutamate receptor ionotropic, NMDA 2C	polymer	880	96958.4	2	UniProt (Q14957) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060)	Homo sapiens (human)	GluN2C,Glutamate [NMDA] receptor subunit epsilon-3,N-methyl D-aspartate receptor subtype 2C,NMDAR2C,NR2C
3	E, H, I, K (E, H, I, K)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	4	In PDB GlyTouCan (G42666HT)
4	F (F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		789.7	1	In PDB GlyTouCan (G95663PY)
5	G, J (G, J)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
6	L, M, N, O, Q... (A, C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG)
7	P (B)	methyl 4-[(2~{R})-3-ethanoyl-1-[2-(2-methyl-1~{H}-indol-3-yl)ethyl]-4-oxidanyl-5-oxidanylidene-2~{H}-pyrrol-2-yl]benzoate	non-polymer		432.5	1	Chemie (IWB)

Sequence modifications

A, C: 1 - 847 (UniProt: Q05586)

PDB	External Database	Details
His 5	Arg 5	conflict
Phe 9	Leu 9	conflict
Phe 17	Val 17	conflict
Ser 22	Cys 22	conflict
Asn 844	Arg 844	conflict
Gly 845	Arg 845	conflict
Ala 846	Lys 846	conflict

B, D: 26 - 849 (UniProt: Q14957)

PDB	External Database	Details
Met -30	-	expression tag
Gly -29	-	expression tag
Thr -28	-	expression tag
Met -27	-	expression tag
Arg -26	-	expression tag
Leu -25	-	expression tag
Phe -24	-	expression tag
Leu -23	-	expression tag
Leu -22	-	expression tag
Ala -21	-	expression tag
Val -20	-	expression tag
Leu -19	-	expression tag
Phe -18	-	expression tag
Leu -17	-	expression tag
Phe -16	-	expression tag
Ser -15	-	expression tag
Phe -14	-	expression tag
Ala -13	-	expression tag
Arg -12	-	expression tag
Ala -11	-	expression tag
Thr -10	-	expression tag
Gly -9	-	expression tag
Trp -8	-	expression tag
Ser -7	-	expression tag
His -6	-	expression tag
Pro -5	-	expression tag
Gln -4	-	expression tag
Phe -3	-	expression tag
Glu -2	-	expression tag
Lys -1	-	expression tag
Gly 0	-	expression tag
Gly 1	-	expression tag
Gly 2	-	expression tag
Ser 3	-	expression tag
Gly 4	-	expression tag
Gly 5	-	expression tag
Gly 6	-	expression tag
Ser 7	-	expression tag
Gly 8	-	expression tag
Gly 9	-	expression tag
Ser 10	-	expression tag
Ala 11	-	expression tag
Trp 12	-	expression tag
Ser 13	-	expression tag
His 14	-	expression tag
Pro 15	-	expression tag
Gln 16	-	expression tag
Phe 17	-	expression tag
Glu 18	-	expression tag
Lys 19	-	expression tag
Gly 20	-	expression tag
Ala 21	-	expression tag
Leu 22	-	expression tag
Val 23	-	expression tag
Pro 24	-	expression tag
Arg 25	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	384080.2
Branched	Number of molecules	7
	Total formula weight	3660.4
Non-Polymers*	Number of molecules	9
	Total formula weight	2202.1
All*	Total formula weight	389942.7

*Water molecules are not included.