8E93
D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in splayed conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Glutamate receptor ionotropic, NMDA 1 | polymer | 847 | 95081.7 | 2 | UniProt (Q05586) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB | Homo sapiens (human) | GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1 |
| 2 | B, D | Glutamate receptor ionotropic, NMDA 2C | polymer | 880 | 96958.4 | 2 | UniProt (Q14957) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB | Homo sapiens (human) | GluN2C,Glutamate [NMDA] receptor subunit epsilon-3,N-methyl D-aspartate receptor subtype 2C,NMDAR2C,NR2C |
| 3 | E, F | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 4 | G, H | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 5 | A, B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) |
Sequence modifications
A, C: 1 - 847 (UniProt: Q05586)
B, D: 26 - 849 (UniProt: Q14957)
| PDB | External Database | Details |
|---|---|---|
| His 5 | Arg 5 | conflict |
| Phe 9 | Leu 9 | conflict |
| Phe 17 | Val 17 | conflict |
| Ser 22 | Cys 22 | conflict |
| Asn 844 | Arg 844 | conflict |
| Gly 845 | Arg 845 | conflict |
| Ala 846 | Lys 846 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -30 | - | expression tag |
| Gly -29 | - | expression tag |
| Thr -28 | - | expression tag |
| Met -27 | - | expression tag |
| Arg -26 | - | expression tag |
| Leu -25 | - | expression tag |
| Phe -24 | - | expression tag |
| Leu -23 | - | expression tag |
| Leu -22 | - | expression tag |
| Ala -21 | - | expression tag |
| Val -20 | - | expression tag |
| Leu -19 | - | expression tag |
| Phe -18 | - | expression tag |
| Leu -17 | - | expression tag |
| Phe -16 | - | expression tag |
| Ser -15 | - | expression tag |
| Phe -14 | - | expression tag |
| Ala -13 | - | expression tag |
| Arg -12 | - | expression tag |
| Ala -11 | - | expression tag |
| Thr -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Trp -8 | - | expression tag |
| Ser -7 | - | expression tag |
| His -6 | - | expression tag |
| Pro -5 | - | expression tag |
| Gln -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Glu -2 | - | expression tag |
| Lys -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Gly 1 | - | expression tag |
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Gly 4 | - | expression tag |
| Gly 5 | - | expression tag |
| Gly 6 | - | expression tag |
| Ser 7 | - | expression tag |
| Gly 8 | - | expression tag |
| Gly 9 | - | expression tag |
| Ser 10 | - | expression tag |
| Ala 11 | - | expression tag |
| Trp 12 | - | expression tag |
| Ser 13 | - | expression tag |
| His 14 | - | expression tag |
| Pro 15 | - | expression tag |
| Gln 16 | - | expression tag |
| Phe 17 | - | expression tag |
| Glu 18 | - | expression tag |
| Lys 19 | - | expression tag |
| Gly 20 | - | expression tag |
| Ala 21 | - | expression tag |
| Leu 22 | - | expression tag |
| Val 23 | - | expression tag |
| Pro 24 | - | expression tag |
| Arg 25 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 384080.2 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2021.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1769.7 | |
| All* | Total formula weight | 387871.7 |
