8E1P
Crystal structure of BG505 SOSIP.v4.1-GT1.2 trimer in complex with gl-PGV20 and PGT124 Fabs
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, E (F, H, N) | germline PGV20 heavy chain | polymer | 225 | 24399.4 | 3 | Homo sapiens (Human) | ||
| 2 | C (I) | germline PGV20 light chain | polymer | 210 | 22229.5 | 1 | Homo sapiens (Human) | ||
| 3 | D, F (L, O) | germline PGV20 light chain | polymer | 210 | 22229.5 | 2 | Homo sapiens (Human) | ||
| 4 | G, H, K (A, C, J) | PGT124 Fab Light Chain | polymer | 214 | 23056.6 | 3 | Homo sapiens (Human) | ||
| 5 | I, J, L (E, G, M) | BG505-SOSIP.v4.1-GT1.2gp120 | polymer | 474 | 53394.7 | 3 | Human immunodeficiency virus 1 (HIV-1) | ||
| 6 | M, N, O (B, D, K) | PGT124 Fab Heavy Chain | polymer | 236 | 25460.5 | 3 | Homo sapiens (Human) | ||
| 7 | P, Q, R (Y, X, Z) | Envelope glycoprotein gp41 | polymer | 153 | 17146.5 | 3 | UniProt (Q2N0S6) Pfam (PF00517) | Human immunodeficiency virus 1 | Env polyprotein |
| 8 | CA, EA, S, X (c, e, P, U) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) | Homo sapiens (Human) | ||
| 9 | BA, DA, FA, IA, T... (b, d, f, i, Q...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 9 | In PDB GlyTouCan (G42666HT) | |||
| 10 | U (R) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G46836GH) | |||
| 11 | AA (a) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1600.4 | 1 | In PDB | |||
| 12 | GA (g) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G94106MV) | |||
| 13 | HA (h) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose | branched | 504.4 | 1 | In PDB GlyTouCan (G25559RS) | |||
| 14 | AB, BB, CB, DB, EB... (M, Y, E, X, Z...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 30 | Chemie (NAG) |
Sequence modifications
Y, X, Z: 512 - 664 (UniProt: Q2N0S6)
| PDB | External Database | Details |
|---|---|---|
| Pro 559 | Ile 556 | conflict |
| Cys 605 | Thr 602 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 497061.5 | |
| Branched | Number of molecules | 17 |
| Total formula weight | 10578.7 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 6636.2 | |
| All* | Total formula weight | 514276.5 |
