8E1O

Crystal structure of hTEAD2 bound to a methoxypyridine lipid pocket binder

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Transcriptional enhancer factor TEF-4	polymer	250	28515.1	2	UniProt (Q15562) Pfam (PF17725)	Homo sapiens (human)	TEA domain family member 2,TEAD-2
2	C (A)	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		122.1	1	Chemie (TRS)
3	D, E (A, B)	5-methoxy-N-({3-[2-(methylamino)-2-oxoethyl]phenyl}methyl)-4-{(E)-2-[trans-4-(trifluoromethyl)cyclohexyl]ethenyl}pyridine-2-carboxamide	non-polymer		489.5	2	Chemie (Y2S)
4	F, G (A, B)	water	water		18.0	22	Chemie (HOH)

Sequence modifications

A, B: 217 - 447 (UniProt: Q15562)

PDB	External Database	Details
Met 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag
His 204	-	expression tag
His 205	-	expression tag
His 206	-	expression tag
His 207	-	expression tag
Gly 208	-	expression tag
Glu 209	-	expression tag
Asn 210	-	expression tag
Leu 211	-	expression tag
Tyr 212	-	expression tag
Phe 213	-	expression tag
Gln 214	-	expression tag
Gly 215	-	expression tag
Ser 216	-	expression tag
Gly 448	-	expression tag
Asn 449	-	expression tag
Ser 450	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	57030.2
Non-Polymers*	Number of molecules	3
	Total formula weight	1101.2
All*	Total formula weight	58131.4

*Water molecules are not included.