8E1A
Structure-based study to overcome cross-reactivity of novel androgen receptor inhibitors
Replaces: 4U4KEntity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Androgen receptor | polymer | 277 | 32141.5 | 1 | UniProt (P10275) Pfam (PF00104) In PDB | Homo sapiens (human) | Dihydrotestosterone receptor,Nuclear receptor subfamily 3 group C member 4 |
2 | A | 4-[4-(3-fluoro-2-methoxyphenyl)-1,3-thiazol-2-yl]morpholine | non-polymer | 294.3 | 1 | Chemie (3E0) | |||
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
4 | water | water | 18.0 | 257 | Chemie (HOH) |
Sequence modifications
A: 664 - 919 (UniProt: P10275)
PDB | External Database | Details |
---|---|---|
Met 643 | - | expression tag |
Gly 644 | - | expression tag |
Ser 645 | - | expression tag |
Ser 646 | - | expression tag |
His 647 | - | expression tag |
His 648 | - | expression tag |
His 649 | - | expression tag |
His 650 | - | expression tag |
His 651 | - | expression tag |
His 652 | - | expression tag |
Ser 653 | - | expression tag |
Ser 654 | - | expression tag |
Gly 655 | - | expression tag |
Leu 656 | - | expression tag |
Val 657 | - | expression tag |
Pro 658 | - | expression tag |
Arg 659 | - | expression tag |
Gly 660 | - | expression tag |
Ser 661 | - | expression tag |
His 662 | - | expression tag |
Met 663 | - | expression tag |
Ala 877 | Thr 878 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 32141.5 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 542.6 | |
All* | Total formula weight | 32684.1 |