8DYS

Crystal structure of human Eukaryotic translation initiation factor 2A (eIF2A)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Eukaryotic translation initiation factor 2A	polymer	603	67271.3	1	UniProt (Q9BY44) Pfam (PF08662)	Homo sapiens (human)	eIF-2A,65 kDa eukaryotic translation initiation factor 2A
2	B, C (A)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
3	D (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	E, F, G (A)	UNKNOWN ATOM OR ION	non-polymer			3	Chemie (UNX)
5	H (A)	water	water		18.0	199	Chemie (HOH)

Sequence modifications

A: 1 - 585 (UniProt: Q9BY44)

PDB	External Database	Details
Met -17	-	initiating methionine
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Arg -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	67271.3
Non-Polymers*	Number of molecules	6
	Total formula weight	216.2
All*	Total formula weight	67487.5

*Water molecules are not included.