8DYJ
Crystal structure of human methylmalonyl-CoA mutase in complex with ADP and cob(II)alamin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Methylmalonyl-CoA mutase, mitochondrial | polymer | 762 | 84835.8 | 1 | UniProt (P22033) Pfam (PF01642) Pfam (PF02310) | Homo sapiens (human) | MCM,Methylmalonyl-CoA isomerase |
| 2 | B (B) | COBALAMIN | non-polymer | 1330.4 | 1 | Chemie (B12) | |||
| 3 | C (B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | D (B) | water | water | 18.0 | 121 | Chemie (HOH) |
Sequence modifications
B: -25 - 713 (UniProt: P22033)
| PDB | External Database | Details |
|---|---|---|
| Met -26 | - | initiating methionine |
| Thr 462 | Ala 499 | conflict |
| Val 634 | Ile 671 | conflict |
| Ala 714 | - | expression tag |
| Glu 715 | - | expression tag |
| Asn 716 | - | expression tag |
| Leu 717 | - | expression tag |
| Tyr 718 | - | expression tag |
| Phe 719 | - | expression tag |
| Gln 720 | - | expression tag |
| Ser 721 | - | expression tag |
| His 722 | - | expression tag |
| His 723 | - | expression tag |
| His 724 | - | expression tag |
| His 725 | - | expression tag |
| His 726 | - | expression tag |
| His 727 | - | expression tag |
| Asp 728 | - | expression tag |
| Tyr 729 | - | expression tag |
| Lys 730 | - | expression tag |
| Asp 731 | - | expression tag |
| Asp 732 | - | expression tag |
| Asp 733 | - | expression tag |
| Asp 734 | - | expression tag |
| Lys 735 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 84835.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1757.6 | |
| All* | Total formula weight | 86593.4 |
