8DYD
Crystal structure of human SDHA-SDHAF2-SDHAF4 assembly intermediate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | polymer | 632 | 69416.4 | 1 | UniProt (P31040) Pfam (PF00890) Pfam (PF02910) In PDB | Homo sapiens (human) | Flavoprotein subunit of complex II,Fp |
| 2 | B | Succinate dehydrogenase assembly factor 2, mitochondrial | polymer | 137 | 16592.8 | 1 | UniProt (Q9NX18) Pfam (PF03937) In PDB | Homo sapiens (human) | SDH assembly factor 2,SDHAF2 |
| 3 | C | Succinate dehydrogenase assembly factor 4, mitochondrial | polymer | 98 | 11227.4 | 1 | UniProt (Q5VUM1) Pfam (PF07896) In PDB | Homo sapiens (human) | SDH assembly factor 4,SDHAF4 |
| 4 | A | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 1 | Chemie (FAD) | |||
| 5 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 2 | Chemie (PG4) | |||
| 6 | A | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 7 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | A, B, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 30 | Chemie (EDO) | |||
| 9 | A, B | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 10 | water | water | 18.0 | 519 | Chemie (HOH) |
Sequence modifications
A: 44 - 664 (UniProt: P31040)
C: 34 - 108 (UniProt: Q5VUM1)
| PDB | External Database | Details |
|---|---|---|
| Met 33 | - | expression tag |
| Arg 34 | - | expression tag |
| Gly 35 | - | expression tag |
| Ser 36 | - | expression tag |
| His 37 | - | expression tag |
| His 38 | - | expression tag |
| His 39 | - | expression tag |
| His 40 | - | expression tag |
| His 41 | - | expression tag |
| His 42 | - | expression tag |
| Gly 43 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 11 | - | initiating methionine |
| Arg 12 | - | expression tag |
| Ser 13 | - | expression tag |
| His 14 | - | expression tag |
| His 15 | - | expression tag |
| His 16 | - | expression tag |
| His 17 | - | expression tag |
| His 18 | - | expression tag |
| His 19 | - | expression tag |
| Glu 20 | - | expression tag |
| Asn 21 | - | expression tag |
| Leu 22 | - | expression tag |
| Tyr 23 | - | expression tag |
| Phe 24 | - | expression tag |
| Gln 25 | - | expression tag |
| Gly 26 | - | expression tag |
| Ile 27 | - | expression tag |
| Asp 28 | - | expression tag |
| Pro 29 | - | expression tag |
| Phe 30 | - | expression tag |
| Thr 31 | - | expression tag |
| Gly 32 | - | expression tag |
| Ser 33 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 97236.7 | |
| Non-Polymers* | Number of molecules | 37 |
| Total formula weight | 3322.8 | |
| All* | Total formula weight | 100559.5 |
