8DXR

Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Volume-regulated anion channel subunit LRRC8C,Volume-regulated anion channel subunit LRRC8A	polymer	825	94747.7	7	UniProt (Q8TDW0) UniProt (Q8IWT6) Pfam (PF12534) Pfam (PF13855) In PDB	Homo sapiens (human)	Factor for adipocyte differentiation 158,Leucine-rich repeat-containing protein 8C,Leucine-rich repeat-containing protein 8A,HsLRRC8A,Swelling protein 1

Sequence modifications

A, B, C, D, E, F, G: 1 - 176 (UniProt: Q8TDW0)
A, B, C, D, E, F, G: 176 - 177 (UniProt: Q8IWT6)

PDB	External Database	Details
Gly 177	-	linker

A, B, C, D, E, F, G: 177 - 802 (UniProt: Q8TDW0)

PDB	External Database	Details
-	Lys 717	deletion
Glu 803	-	expression tag
Asn 804	-	expression tag
Leu 805	-	expression tag
Tyr 806	-	expression tag
Phe 807	-	expression tag
Gln 808	-	expression tag
Gly 809	-	expression tag
Ala 810	-	expression tag
Ala 811	-	expression tag
Ala 812	-	expression tag
Gly 813	-	expression tag
Asp 814	-	expression tag
Tyr 815	-	expression tag
Lys 816	-	expression tag
Asp 817	-	expression tag
Asp 818	-	expression tag
Asp 819	-	expression tag
Asp 820	-	expression tag
Lys 821	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	663233.9
All*	Total formula weight	663233.9

*Water molecules are not included.