8DVE
RyR1 in presence of IpCa-T26E phosphomimetic and activating ligands
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | D, A, G, J | Ryanodine receptor 1 | polymer | 5037 | 565908.6 | 4 | UniProt (P11716) Pfam (PF08709) Pfam (PF01365) Pfam (PF02026) Pfam (PF08454) Pfam (PF06459) Pfam (PF00520) Pfam (PF02815) Pfam (PF00622) Pfam (PF21119) In PDB | Oryctolagus cuniculus (rabbit) | RYR-1,RyR1,Skeletal muscle calcium release channel,Skeletal muscle ryanodine receptor,Skeletal muscle-type ryanodine receptor,Type 1 ryanodine receptor |
| 2 | E, B, H, K | Peptidyl-prolyl cis-trans isomerase FKBP1B | polymer | 107 | 11667.3 | 4 | UniProt (P68106) Pfam (PF00254) In PDB | Homo sapiens (human) | PPIase FKBP1B,12.6 kDa FK506-binding protein,FKBP-12.6,FK506-binding protein 1B,FKBP-1B,Immunophilin FKBP12.6,Rotamase,h-FKBP-12 |
| 3 | F, C, I, L | Calmodulin-1 | polymer | 149 | 16620.4 | 4 | UniProt (P0DP23) Pfam (PF13499) In PDB | Homo sapiens (human) | |
| 4 | D, A, G, J | CAFFEINE | non-polymer | 194.2 | 4 | Chemie (CFF) | |||
| 5 | D, A, G, J | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 6 | J, D, A, G | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 4 | Chemie (ATP) | |||
| 7 | J, D, A, G | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) |
Sequence modifications
F, C, I, L: 1 - 149 (UniProt: P0DP23)
| PDB | External Database | Details |
|---|---|---|
| Ala 32 | Glu 32 | engineered mutation |
| Ala 68 | Glu 68 | engineered mutation |
| Ala 105 | Glu 105 | engineered mutation |
| Ala 141 | Glu 141 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 2376785.3 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 3227.4 | |
| All* | Total formula weight | 2380012.8 |
