8DU4
Complex between RbBP5-WDR5 and an H2B-ubiquitinated nucleosome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E | Histone H3 | polymer | 136 | 15383.0 | 2 | UniProt (A0A310TTQ1) Pfam (PF00125) UniProt (by SIFTS) (P02302) In PDB | Xenopus laevis (African clawed frog) | |
| 2 | B, F | Histone H4 | polymer | 103 | 11394.4 | 2 | UniProt (P62799) Pfam (PF15511) In PDB | Xenopus laevis (African clawed frog) | |
| 3 | C, G | Histone H2A | polymer | 130 | 14109.4 | 2 | UniProt (Q6AZJ8) Pfam (PF00125) Pfam (PF16211) UniProt (by SIFTS) (P06897) In PDB | Xenopus laevis (African clawed frog) | |
| 4 | D, H | Histone H2B 1.1 | polymer | 123 | 13629.9 | 2 | UniProt (P02281) Pfam (PF00125) In PDB | Xenopus laevis (African clawed frog) | H2B1.1 |
| 5 | I | 601 DNA (146-MER) | polymer | 146 | 44825.6 | 1 | synthetic construct | ||
| 6 | J | 601 DNA (146-MER) | polymer | 146 | 45305.9 | 1 | synthetic construct | ||
| 7 | L | WD repeat-containing protein 5 | polymer | 335 | 36648.4 | 1 | UniProt (P61964) Pfam (PF00400) In PDB | Homo sapiens (human) | BMP2-induced 3-kb gene protein |
| 8 | N | Retinoblastoma-binding protein 5 | polymer | 538 | 59223.5 | 1 | UniProt (Q15291) Pfam (PF00400) In PDB | Homo sapiens (human) | RBBP-5,Retinoblastoma-binding protein RBQ-3 |
| 9 | O | Polyubiquitin-B | polymer | 81 | 9164.5 | 1 | UniProt (J3QS39) Pfam (PF00240) UniProt (by SIFTS) (P0CG47) In PDB | Homo sapiens (human) |
Sequence modifications
A, E: 0 - 135 (UniProt: A0A310TTQ1)
D, H: 1 - 122 (UniProt: P02281)
L: 2 - 334 (UniProt: P61964)
O: 1 - 76 (UniProt: J3QS39)
| PDB | External Database | Details |
|---|---|---|
| Nle 4 | Lys 5 | engineered mutation |
| Nle 90 | Met 91 | engineered mutation |
| Nle 120 | Met 121 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | expression tag |
| Thr 29 | Ser 33 | engineered mutation |
| Cys 117 | Lys 121 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gln -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
| Cys 76 | Gly 76 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 13 |
| Total formula weight | 304201.4 | |
| All* | Total formula weight | 304201.4 |
