Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8DU4

Complex between RbBP5-WDR5 and an H2B-ubiquitinated nucleosome

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0030527	molecular_function	structural constituent of chromatin
A	0046982	molecular_function	protein heterodimerization activity
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0006334	biological_process	nucleosome assembly
B	0030527	molecular_function	structural constituent of chromatin
B	0046982	molecular_function	protein heterodimerization activity
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0030527	molecular_function	structural constituent of chromatin
C	0046982	molecular_function	protein heterodimerization activity
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0030527	molecular_function	structural constituent of chromatin
D	0046982	molecular_function	protein heterodimerization activity
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0030527	molecular_function	structural constituent of chromatin
E	0046982	molecular_function	protein heterodimerization activity
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0006334	biological_process	nucleosome assembly
F	0030527	molecular_function	structural constituent of chromatin
F	0046982	molecular_function	protein heterodimerization activity
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0030527	molecular_function	structural constituent of chromatin
G	0046982	molecular_function	protein heterodimerization activity
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005694	cellular_component	chromosome
H	0030527	molecular_function	structural constituent of chromatin
H	0046982	molecular_function	protein heterodimerization activity
L	0000122	biological_process	negative regulation of transcription by RNA polymerase II
L	0000123	cellular_component	histone acetyltransferase complex
L	0001501	biological_process	skeletal system development
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0006094	biological_process	gluconeogenesis
L	0006325	biological_process	chromatin organization
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0035064	molecular_function	methylated histone binding
L	0035097	cellular_component	histone methyltransferase complex
L	0042393	molecular_function	histone binding
L	0042800	molecular_function	histone H3K4 methyltransferase activity
L	0044545	cellular_component	NSL complex
L	0044665	cellular_component	MLL1/2 complex
L	0044666	cellular_component	MLL3/4 complex
L	0045722	biological_process	positive regulation of gluconeogenesis
L	0045815	biological_process	transcription initiation-coupled chromatin remodeling
L	0045893	biological_process	positive regulation of DNA-templated transcription
L	0045995	biological_process	regulation of embryonic development
L	0048188	cellular_component	Set1C/COMPASS complex
L	0051302	biological_process	regulation of cell division
L	0051726	biological_process	regulation of cell cycle
L	0071339	cellular_component	MLL1 complex
L	0072686	cellular_component	mitotic spindle
L	0090043	biological_process	regulation of tubulin deacetylation
L	0140672	cellular_component	ATAC complex
N	0000976	molecular_function	transcription cis-regulatory region binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005730	cellular_component	nucleolus
N	0006325	biological_process	chromatin organization
N	0006974	biological_process	DNA damage response
N	0035097	cellular_component	histone methyltransferase complex
N	0042393	molecular_function	histone binding
N	0043627	biological_process	response to estrogen
N	0044665	cellular_component	MLL1/2 complex
N	0044666	cellular_component	MLL3/4 complex
N	0045815	biological_process	transcription initiation-coupled chromatin remodeling
N	0048188	cellular_component	Set1C/COMPASS complex
N	0071339	cellular_component	MLL1 complex

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA21-VAL27

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
O	LYS27-ASP52

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG89-GLY111

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV

Chain	Residue	Details
L	LEU102-VAL116
L	ILE144-VAL158
L	ILE186-THR200
L	ILE274-LEU288

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250

Chain	Residue	Details
C	SER1
G	SER1
L	PHE263
L	GLU322
H	LYS2
H	LYS9
H	LYS12
H	LYS17

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250

Chain	Residue	Details
C	LYS5
G	LYS5

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:P0C0S8

Chain	Residue	Details
C	LYS9
C	LYS95
G	LYS9
G	LYS95

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine; alternate => ECO:0000250\|UniProtKB:P0C0S8

Chain	Residue	Details
C	LYS36
G	LYS36
L	LYS27
L	LYS46

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000250\|UniProtKB:P0C0S8

Chain	Residue	Details
C	LYS74
C	LYS75
G	LYS74
G	LYS75
F	LYS8
F	LYS16
F	LYS44
F	LYS79

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N5-methylglutamine => ECO:0000250

Chain	Residue	Details
C	GLN104
G	GLN104
E	LYS9
E	LYS64

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250\|UniProtKB:P0C0S8

Chain	Residue	Details
C	LYS118
G	LYS118
F	LYS31
F	LYS91

site_id	SWS_FT_FI8
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250

Chain	Residue	Details
C	LYS13
E	LYS14
C	LYS15
C	LYS119
G	LYS13
G	LYS15
G	LYS119

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Asymmetric dimethylarginine => ECO:0000250\|UniProtKB:P84243

Chain	Residue	Details
A	ARG17
E	ARG17
F	TYR51
F	TYR88

site_id	SWS_FT_FI10
Number of Residues	6
Details	MOD_RES: N6-methylated lysine; alternate => ECO:0000250\|UniProtKB:P84243

Chain	Residue	Details
A	LYS18
A	LYS27
A	LYS36
E	LYS18
E	LYS27
E	LYS36

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: N6-lactoyllysine; alternate => ECO:0000250\|UniProtKB:P68431

Chain	Residue	Details
A	LYS23
E	LYS23

site_id	SWS_FT_FI12
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P84243

Chain	Residue	Details
A	TYR41
E	TYR41

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P84244

Chain	Residue	Details
A	LYS56
A	LYS79
E	LYS56
E	LYS79

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P84243

Chain	Residue	Details
A	SER57
E	SER57

site_id	SWS_FT_FI15
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P84243

Chain	Residue	Details
A	THR80
E	THR80

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250\|UniProtKB:P84243

Chain	Residue	Details
A	LYS115
E	LYS115

site_id	SWS_FT_FI17
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P84243

Chain	Residue	Details
A	LYS122
E	LYS122

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)