8DTJ

Human NAMPT in complex with small molecule activator ZN-43-S

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Nicotinamide phosphoribosyltransferase	polymer	499	56666.1	2	UniProt (P43490) Pfam (PF18127) Pfam (PF04095)	Homo sapiens (human)	NAmPRTase,Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin
2	C, F (A, B)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
3	D, G, H (A, B)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
4	E, I (A, B)	(3S)-N-[(1-benzothiophen-5-yl)methyl]-1-{2-[4-(trifluoromethyl)phenyl]-2H-pyrazolo[3,4-d]pyrimidin-4-yl}piperidine-3-carboxamide	non-polymer		536.6	2	Chemie (TKF)
5	J (B)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
6	K, L (A, B)	water	water		18.0	407	Chemie (HOH)

Sequence modifications

A, B: 1 - 491 (UniProt: P43490)

PDB	External Database	Details
Leu 492	-	expression tag
Glu 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag
His 499	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	113332.2
Non-Polymers*	Number of molecules	8
	Total formula weight	1574.8
All*	Total formula weight	114907.0

*Water molecules are not included.