8DSW
Crystal structure of EGFR kinase domain, Exon20 Insertion FQEA mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 335 | 38111.9 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B, C (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 2 | Chemie (PG4) | |||
| 3 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | E (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 5 | F (A) | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A: 696 - 1026 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 692 | - | expression tag |
| Ser 693 | - | expression tag |
| Thr 694 | - | expression tag |
| Ser 695 | - | expression tag |
| Phe 764 | - | insertion |
| Gln 765 | - | insertion |
| Glu 766 | - | insertion |
| Ala 767 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38111.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 919.0 | |
| All* | Total formula weight | 39030.9 |
