8DRZ
Product structure of SARS-CoV-2 Mpro C145A mutant in complex with nsp13-nsp14 (C13) cut site sequence
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | 3C-like proteinase nsp5 | polymer | 306 | 33800.5 | 7 | UniProt (P0DTD1) Pfam (PF05409) | Severe acute respiratory syndrome coronavirus 2 | 3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase |
| 2 | CA, DA, EA, H, J... (F, A, C, D) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 10 | Chemie (PEG) | |||
| 3 | AA, FA, HA, I, L... (E, F, G, A, B...) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 10 | Chemie (TRS) | |||
| 4 | K, R, Z (A, B, D) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 3 | Chemie (1PE) | |||
| 5 | BA, GA, O, S (F, G, B, C) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 6 | IA, JA, KA, LA, MA... (A, B, C, D, E...) | water | water | 18.0 | 1395 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G: 1 - 300 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Ala 145 | Cys 3408 | engineered mutation |
| Asn 301 | - | expression tag |
| Val 302 | - | expression tag |
| Ala 303 | - | expression tag |
| Thr 304 | - | expression tag |
| Leu 305 | - | expression tag |
| Gln 306 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 236603.6 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 3089.4 | |
| All* | Total formula weight | 239693.0 |
