8DRZ

Product structure of SARS-CoV-2 Mpro C145A mutant in complex with nsp13-nsp14 (C13) cut site sequence

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008233	molecular_function	peptidase activity
A	0019082	biological_process	viral protein processing
B	0008233	molecular_function	peptidase activity
B	0019082	biological_process	viral protein processing
C	0008233	molecular_function	peptidase activity
C	0019082	biological_process	viral protein processing
D	0008233	molecular_function	peptidase activity
D	0019082	biological_process	viral protein processing
E	0008233	molecular_function	peptidase activity
E	0019082	biological_process	viral protein processing
F	0008233	molecular_function	peptidase activity
F	0019082	biological_process	viral protein processing
G	0008233	molecular_function	peptidase activity
G	0019082	biological_process	viral protein processing

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	ACT_SITE: For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000305|PubMed:32198291

Chain	Residue	Details
A	HIS41
B	HIS41
C	HIS41
D	HIS41
E	HIS41
F	HIS41
G	HIS41

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site_id	SWS_FT_FI2
Number of Residues	7
Details	ACT_SITE: Nucleophile; for 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:32198291

Chain	Residue	Details
A	ALA145
B	ALA145
C	ALA145
D	ALA145
E	ALA145
F	ALA145
G	ALA145

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site_id	SWS_FT_FI3
Number of Residues	21
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:39223933

Chain	Residue	Details
A	LYS5
D	LYS5
D	LYS90
E	LYS5
E	LYS90
F	LYS5
F	LYS90
G	LYS5
G	LYS90
A	LYS90
B	LYS5
B	LYS90
C	LYS5
C	LYS90

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