8DRY

Product structure of SARS-CoV-2 Mpro C145A mutant in complex with nsp12-nsp13 (C12) cut site sequence

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Fusion protein of 3C-like proteinase nsp5 and nsp12-nsp13 (C12) cut site	polymer	306	33850.6	12	UniProt (P0DTD1) Pfam (PF05409)	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 2019-nCoV)	3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase,Pol,RdRp,Non-structural protein 12,nsp12
2	M, N (B, E)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
3	O, P, Q, R, S... (A, B, C, D, E...)	water	water		18.0	159	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L: 1 - 300 (UniProt: P0DTD1)

PDB	External Database	Details
Ala 145	Cys 3408	engineered mutation

A, B, C, D, E, F, G, H, I, J, K, L: 301 - 306 (UniProt: P0DTD1)

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	406207.1
Non-Polymers*	Number of molecules	2
	Total formula weight	212.2
All*	Total formula weight	406419.4

*Water molecules are not included.