8DRY
Product structure of SARS-CoV-2 Mpro C145A mutant in complex with nsp12-nsp13 (C12) cut site sequence
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0019082 | biological_process | viral protein processing |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0019082 | biological_process | viral protein processing |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0019082 | biological_process | viral protein processing |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0019082 | biological_process | viral protein processing |
| E | 0008233 | molecular_function | peptidase activity |
| E | 0019082 | biological_process | viral protein processing |
| F | 0008233 | molecular_function | peptidase activity |
| F | 0019082 | biological_process | viral protein processing |
| G | 0008233 | molecular_function | peptidase activity |
| G | 0019082 | biological_process | viral protein processing |
| H | 0008233 | molecular_function | peptidase activity |
| H | 0019082 | biological_process | viral protein processing |
| I | 0008233 | molecular_function | peptidase activity |
| I | 0019082 | biological_process | viral protein processing |
| J | 0008233 | molecular_function | peptidase activity |
| J | 0019082 | biological_process | viral protein processing |
| K | 0008233 | molecular_function | peptidase activity |
| K | 0019082 | biological_process | viral protein processing |
| L | 0008233 | molecular_function | peptidase activity |
| L | 0019082 | biological_process | viral protein processing |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000305|PubMed:32198291 |
| Chain | Residue | Details |
| A | HIS41 | |
| B | HIS41 | |
| C | HIS41 | |
| D | HIS41 | |
| E | HIS41 | |
| F | HIS41 | |
| G | HIS41 | |
| H | HIS41 | |
| I | HIS41 | |
| J | HIS41 | |
| K | HIS41 | |
| L | HIS41 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | ACT_SITE: Nucleophile; for 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:32198291 |
| Chain | Residue | Details |
| A | ALA145 | |
| B | ALA145 | |
| C | ALA145 | |
| D | ALA145 | |
| E | ALA145 | |
| F | ALA145 | |
| G | ALA145 | |
| H | ALA145 | |
| I | ALA145 | |
| J | ALA145 | |
| K | ALA145 | |
| L | ALA145 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3 |
| Chain | Residue | Details |
| A | GLN306 | |
| B | GLN306 | |
| C | GLN306 | |
| D | GLN306 | |
| E | GLN306 | |
| F | GLN306 | |
| G | GLN306 | |
| H | GLN306 | |
| I | GLN306 | |
| J | GLN306 | |
| K | GLN306 | |
| L | GLN306 |
