8DPU

The crystal structure of the IL-11 signalling complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J, M...	Interleukin-6 receptor subunit beta	polymer	303	34564.0	6	UniProt (P40189) Pfam (PF06328) Pfam (PF09240) Pfam (PF00041) In PDB	Homo sapiens (human)	IL-6 receptor subunit beta,IL-6R subunit beta,IL-6R-beta,IL-6RB,CDw130,Interleukin-6 signal transducer,Membrane glycoprotein 130,gp130,Oncostatin-M receptor subunit alpha
2	B, E, H, K, N...	Interleukin-11	polymer	179	19226.4	6	UniProt (P20809) Pfam (PF07400) In PDB	Homo sapiens (human)	IL-11,Adipogenesis inhibitory factor,AGIF
3	C, F, I, L, O...	Interleukin-11 receptor subunit alpha	polymer	348	38073.5	6	UniProt (Q14626) In PDB	Homo sapiens (human)	IL-11 receptor subunit alpha,IL-11R subunit alpha,IL-11R-alpha,IL-11RA
4	a, c, S, U, W...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	6	In PDB GlyTouCan (G42666HT)
5	b, d, T, V, X...	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	6	In PDB GlyTouCan (G15407YE)
6	A, C, D, F, G...	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	18	Chemie (NAG)

Sequence modifications

B, E, H, K, N, Q: 1 - 178 (UniProt: P20809)

PDB	External Database	Details
Gly 0	-	expression tag

C, F, I, L, O, R: 1 - 341 (UniProt: Q14626)

PDB	External Database	Details
Ser 226	Cys 248	engineered mutation
His 342	-	expression tag
His 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
His 346	-	expression tag
His 347	-	expression tag
His 348	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	18
	Total formula weight	551183.3
Branched	Number of molecules	12
	Total formula weight	6065.7
Non-Polymers*	Number of molecules	18
	Total formula weight	3981.7
All*	Total formula weight	561230.7

*Water molecules are not included.