Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8DPU

The crystal structure of the IL-11 signalling complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0001960	biological_process	negative regulation of cytokine-mediated signaling pathway
B	0005125	molecular_function	cytokine activity
B	0005142	molecular_function	interleukin-11 receptor binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0008083	molecular_function	growth factor activity
B	0008284	biological_process	positive regulation of cell population proliferation
B	0030183	biological_process	B cell differentiation
B	0030219	biological_process	megakaryocyte differentiation
B	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
B	0038154	biological_process	interleukin-11-mediated signaling pathway
B	0043235	cellular_component	receptor complex
B	0043410	biological_process	positive regulation of MAPK cascade
B	0045444	biological_process	fat cell differentiation
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046888	biological_process	negative regulation of hormone secretion
B	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
B	0060302	biological_process	negative regulation of cytokine activity
B	1903659	biological_process	regulation of complement-dependent cytotoxicity
B	2000352	biological_process	negative regulation of endothelial cell apoptotic process
C	0004896	molecular_function	cytokine receptor activity
C	0016020	cellular_component	membrane
E	0001960	biological_process	negative regulation of cytokine-mediated signaling pathway
E	0005125	molecular_function	cytokine activity
E	0005142	molecular_function	interleukin-11 receptor binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005737	cellular_component	cytoplasm
E	0008083	molecular_function	growth factor activity
E	0008284	biological_process	positive regulation of cell population proliferation
E	0030183	biological_process	B cell differentiation
E	0030219	biological_process	megakaryocyte differentiation
E	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
E	0038154	biological_process	interleukin-11-mediated signaling pathway
E	0043235	cellular_component	receptor complex
E	0043410	biological_process	positive regulation of MAPK cascade
E	0045444	biological_process	fat cell differentiation
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0046888	biological_process	negative regulation of hormone secretion
E	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
E	0060302	biological_process	negative regulation of cytokine activity
E	1903659	biological_process	regulation of complement-dependent cytotoxicity
E	2000352	biological_process	negative regulation of endothelial cell apoptotic process
F	0004896	molecular_function	cytokine receptor activity
F	0016020	cellular_component	membrane
H	0001960	biological_process	negative regulation of cytokine-mediated signaling pathway
H	0005125	molecular_function	cytokine activity
H	0005142	molecular_function	interleukin-11 receptor binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005737	cellular_component	cytoplasm
H	0008083	molecular_function	growth factor activity
H	0008284	biological_process	positive regulation of cell population proliferation
H	0030183	biological_process	B cell differentiation
H	0030219	biological_process	megakaryocyte differentiation
H	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
H	0038154	biological_process	interleukin-11-mediated signaling pathway
H	0043235	cellular_component	receptor complex
H	0043410	biological_process	positive regulation of MAPK cascade
H	0045444	biological_process	fat cell differentiation
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0046888	biological_process	negative regulation of hormone secretion
H	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
H	0060302	biological_process	negative regulation of cytokine activity
H	1903659	biological_process	regulation of complement-dependent cytotoxicity
H	2000352	biological_process	negative regulation of endothelial cell apoptotic process
I	0004896	molecular_function	cytokine receptor activity
I	0016020	cellular_component	membrane
K	0001960	biological_process	negative regulation of cytokine-mediated signaling pathway
K	0005125	molecular_function	cytokine activity
K	0005142	molecular_function	interleukin-11 receptor binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005737	cellular_component	cytoplasm
K	0008083	molecular_function	growth factor activity
K	0008284	biological_process	positive regulation of cell population proliferation
K	0030183	biological_process	B cell differentiation
K	0030219	biological_process	megakaryocyte differentiation
K	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
K	0038154	biological_process	interleukin-11-mediated signaling pathway
K	0043235	cellular_component	receptor complex
K	0043410	biological_process	positive regulation of MAPK cascade
K	0045444	biological_process	fat cell differentiation
K	0045944	biological_process	positive regulation of transcription by RNA polymerase II
K	0046888	biological_process	negative regulation of hormone secretion
K	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
K	0060302	biological_process	negative regulation of cytokine activity
K	1903659	biological_process	regulation of complement-dependent cytotoxicity
K	2000352	biological_process	negative regulation of endothelial cell apoptotic process
L	0004896	molecular_function	cytokine receptor activity
L	0016020	cellular_component	membrane
N	0001960	biological_process	negative regulation of cytokine-mediated signaling pathway
N	0005125	molecular_function	cytokine activity
N	0005142	molecular_function	interleukin-11 receptor binding
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0005737	cellular_component	cytoplasm
N	0008083	molecular_function	growth factor activity
N	0008284	biological_process	positive regulation of cell population proliferation
N	0030183	biological_process	B cell differentiation
N	0030219	biological_process	megakaryocyte differentiation
N	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
N	0038154	biological_process	interleukin-11-mediated signaling pathway
N	0043235	cellular_component	receptor complex
N	0043410	biological_process	positive regulation of MAPK cascade
N	0045444	biological_process	fat cell differentiation
N	0045944	biological_process	positive regulation of transcription by RNA polymerase II
N	0046888	biological_process	negative regulation of hormone secretion
N	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
N	0060302	biological_process	negative regulation of cytokine activity
N	1903659	biological_process	regulation of complement-dependent cytotoxicity
N	2000352	biological_process	negative regulation of endothelial cell apoptotic process
O	0004896	molecular_function	cytokine receptor activity
O	0016020	cellular_component	membrane
Q	0001960	biological_process	negative regulation of cytokine-mediated signaling pathway
Q	0005125	molecular_function	cytokine activity
Q	0005142	molecular_function	interleukin-11 receptor binding
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005615	cellular_component	extracellular space
Q	0005737	cellular_component	cytoplasm
Q	0008083	molecular_function	growth factor activity
Q	0008284	biological_process	positive regulation of cell population proliferation
Q	0030183	biological_process	B cell differentiation
Q	0030219	biological_process	megakaryocyte differentiation
Q	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
Q	0038154	biological_process	interleukin-11-mediated signaling pathway
Q	0043235	cellular_component	receptor complex
Q	0043410	biological_process	positive regulation of MAPK cascade
Q	0045444	biological_process	fat cell differentiation
Q	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Q	0046888	biological_process	negative regulation of hormone secretion
Q	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
Q	0060302	biological_process	negative regulation of cytokine activity
Q	1903659	biological_process	regulation of complement-dependent cytotoxicity
Q	2000352	biological_process	negative regulation of endothelial cell apoptotic process
R	0004896	molecular_function	cytokine receptor activity
R	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS01354
Number of Residues	43
Details	HEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. LrPDPPqgLrvesvpgyprrLrasWtyPaSWpsqph.FlLkFrL

Chain	Residue	Details
C	LEU194-LEU236

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1062
Details	Domain: {"description":"Ig-like C2-type"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	546
Details	Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	48
Details	Motif: {"description":"WSXWS motif"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	48
Details	Region: {"description":"Important for interaction with IL11RA and for the stimulation of cell proliferation","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	6
Details	Site: {"description":"Important for interaction with IL6ST and for the stimulation of cell proliferation","evidences":[{"source":"UniProtKB","id":"P47873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	12
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)