8DN2
Cryo-EM structure of human Glycine Receptor alpha1-beta heteromer, glycine-bound state 2(expanded open)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | D, A, B, C | Glycine receptor subunit alpha-1 | polymer | 367 | 42421.1 | 4 | UniProt (P23415) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (human) | Glycine receptor 48 kDa subunit,Glycine receptor strychnine-binding subunit |
2 | E | Glycine receptor subunit beta,Green fluorescent protein,Glycine receptor beta | polymer | 680 | 76584.5 | 1 | UniProt (P48167) UniProt (P42212) UniProt (A0A2K6CAQ3) Pfam (PF02931) Pfam (PF02932) Pfam (PF01353) In PDB | Homo sapiens (human) | Glycine receptor 58 kDa subunit |
3 | B, D, C, E, A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
4 | B, D, C, E, A | HEXANE | non-polymer | 86.2 | 10 | Chemie (HEX) | |||
5 | B, D, C, E | HEPTANE | non-polymer | 100.2 | 9 | Chemie (HP6) | |||
6 | B, D, A | UNDECANE | non-polymer | 156.3 | 3 | Chemie (UND) | |||
7 | C, D, E, A | N-OCTANE | non-polymer | 114.2 | 7 | Chemie (OCT) | |||
8 | B, C, A | GLYCINE | non-polymer | 75.1 | 3 | Chemie (GLY) | |||
9 | E, A | nonane | non-polymer | 128.3 | 2 | Chemie (DD9) | |||
10 | C, A | N-BUTANE | non-polymer | 58.1 | 3 | Chemie (NBU) | |||
11 | E | DECANE | non-polymer | 142.3 | 1 | Chemie (D10) |
Sequence modifications
D, A, B, C: 1 - 428 (UniProt: P23415)
E: 3 - 333 (UniProt: P48167)
E: 333 - 342 (UniProt: P42212)
E: 342 - 475 (UniProt: A0A2K6CAQ3)
PDB | External Database | Details |
---|---|---|
- | Arg 344 | deletion |
- | Phe 345 | deletion |
- | Arg 346 | deletion |
- | Arg 347 | deletion |
- | Lys 348 | deletion |
- | Arg 349 | deletion |
- | Arg 350 | deletion |
- | His 351 | deletion |
- | His 352 | deletion |
- | Lys 353 | deletion |
- | Ser 354 | deletion |
- | Pro 355 | deletion |
- | Met 356 | deletion |
- | Leu 357 | deletion |
- | Asn 358 | deletion |
- | Leu 359 | deletion |
- | Phe 360 | deletion |
- | Gln 361 | deletion |
- | Glu 362 | deletion |
- | Asp 363 | deletion |
- | Glu 364 | deletion |
- | Ala 365 | deletion |
- | Gly 366 | deletion |
- | Glu 367 | deletion |
- | Gly 368 | deletion |
- | Arg 369 | deletion |
- | Phe 370 | deletion |
- | Asn 371 | deletion |
- | Phe 372 | deletion |
- | Ser 373 | deletion |
- | Ala 374 | deletion |
- | Tyr 375 | deletion |
- | Gly 376 | deletion |
- | Met 377 | deletion |
- | Gly 378 | deletion |
- | Pro 379 | deletion |
- | Ala 380 | deletion |
- | Cys 381 | deletion |
- | Leu 382 | deletion |
- | Gln 383 | deletion |
- | Ala 384 | deletion |
- | Lys 385 | deletion |
- | Asp 386 | deletion |
- | Gly 387 | deletion |
- | Ile 388 | deletion |
- | Ser 389 | deletion |
- | Val 390 | deletion |
- | Lys 391 | deletion |
- | Gly 392 | deletion |
- | Ala 393 | deletion |
- | Asn 394 | deletion |
- | Asn 395 | deletion |
- | Ser 396 | deletion |
- | Asn 397 | deletion |
- | Thr 398 | deletion |
- | Thr 399 | deletion |
- | Asn 400 | deletion |
- | Pro 401 | deletion |
- | Pro 402 | deletion |
- | Pro 403 | deletion |
- | Ala 404 | deletion |
- | Pro 405 | deletion |
Gly 377 | Ser 406 | conflict |
Ser 378 | Lys 407 | conflict |
Gly 380 | Pro 409 | conflict |
PDB | External Database | Details |
---|---|---|
Gly 333 | - | linker |
Gly 333 | - | linker |
Ser 333 | - | linker |
Ser 333 | - | linker |
Ala 333 | - | linker |
Ala 333 | - | linker |
Ala 333 | - | linker |
PDB | External Database | Details |
---|---|---|
Val 333 | Met 1 | conflict |
Ser 342 | - | linker |
Gly 342 | - | linker |
PDB | External Database | Details |
---|---|---|
Gly 342 | Thr 380 | conflict |
Ser 342 | Leu 381 | conflict |
Gly 342 | Gln 382 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 246269.0 | |
Non-Polymers* | Number of molecules | 43 |
Total formula weight | 4936.5 | |
All* | Total formula weight | 251205.5 |