8DN2
Cryo-EM structure of human Glycine Receptor alpha1-beta heteromer, glycine-bound state 2(expanded open)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016594 | molecular_function | glycine binding |
| A | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016594 | molecular_function | glycine binding |
| B | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0016594 | molecular_function | glycine binding |
| C | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0016594 | molecular_function | glycine binding |
| D | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0006091 | biological_process | generation of precursor metabolites and energy |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0008218 | biological_process | bioluminescence |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS00236 |
| Number of Residues | 15 |
| Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpMdLknFPmDvqtC |
| Chain | Residue | Details |
| D | CYS138-CYS152 | |
| E | CYS161-CYS175 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:34473954, ECO:0007744|PDB:5BKF |
| Chain | Residue | Details |
| E | TYR247-TRP267 | |
| A | ALA1-TYR222 | |
| B | ALA1-TYR222 | |
| C | ALA1-TYR222 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:34473954, ECO:0007744|PDB:5BKF |
| Chain | Residue | Details |
| E | ILE268-ALA272 | |
| A | TYR223-ILE244 | |
| B | TYR223-ILE244 | |
| C | TYR223-ILE244 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:34473954, ECO:0007744|PDB:5BKF |
| Chain | Residue | Details |
| E | SER273-THR293 | |
| A | ASN245-ALA249 | |
| B | ASN245-ALA249 | |
| C | ASN245-ALA249 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 11 |
| Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:34473954, ECO:0007744|PDB:5BKF |
| Chain | Residue | Details |
| E | LEU294-LYS305 | |
| A | PRO250-SER270 | |
| B | PRO250-SER270 | |
| C | PRO250-SER270 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:34473954, ECO:0007744|PDB:5BKF |
| Chain | Residue | Details |
| E | ALA306-VAL327 | |
| A | ARG271-LYS281 | |
| B | ARG271-LYS281 | |
| C | ARG271-LYS281 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:34473954, ECO:0007744|PDB:5BKF |
| Chain | Residue | Details |
| E | ILE451-TYR474 | |
| A | ALA282-ALA302 | |
| B | ALA282-ALA302 | |
| C | ALA282-ALA302 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34473954, ECO:0000269|PubMed:37821459, ECO:0007744|PDB:5BKF, ECO:0007744|PDB:8DN5 |
| Chain | Residue | Details |
| E | ARG86 | |
| E | SER152 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34473954, ECO:0007744|PDB:5BKF |
| Chain | Residue | Details |
| E | THR228 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | SITE: Important for obstruction of the ion pore in the closed conformation => ECO:0000250|UniProtKB:P23415 |
| Chain | Residue | Details |
| E | LEU285 | |
| C | ARG65 | |
| C | SER129 | |
| C | THR204 | |
| D | SER129 | |
| D | THR204 | |
| A | ARG65 | |
| A | SER129 | |
| A | THR204 | |
| B | ARG65 | |
| B | SER129 | |
| B | THR204 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:34473954 |
| Chain | Residue | Details |
| E | ASN32 | |
| C | GLU192 | |
| C | ASP194 | |
| C | HIS215 | |
| E | ASN220 | |
| D | HIS215 | |
| A | GLU192 | |
| A | ASP194 | |
| A | HIS215 | |
| B | GLU192 | |
| B | ASP194 | |
| B | HIS215 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: (Z)-2,3-didehydrotyrosine => ECO:0000269|PubMed:8448132 |
| Chain | Residue | Details |
| E | TYR335 | |
| A | TYR202 | |
| B | TYR202 | |
| C | TYR202 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CROSSLNK: 5-imidazolinone (Ser-Gly) => ECO:0000269|PubMed:8448132 |
| Chain | Residue | Details |
| E | SER335 | |
| E | GLY335 | |
| B | LEU261 | |
| C | LEU261 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305 |
| Chain | Residue | Details |
| D | ASN38 | |
| A | ASN38 | |
| B | ASN38 | |
| C | ASN38 |
