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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8DHB

Active FLCN GAP complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Ras-related GTP-binding protein Cpolymer40044384.01UniProt (Q9HB90)
Pfam (PF04670)		Homo sapiens (human)Rag C,RagC,GTPase-interacting protein 2,TIB929
2B
(B)		Ras-related GTP-binding protein Apolymer33639362.11UniProt (Q7L523)
Pfam (PF04670)		Homo sapiens (human)RagA,Adenovirus E3 14.7 kDa-interacting protein 1,FIP-1
3C
(C)		Ragulator complex protein LAMTOR1polymer16618325.31UniProt (Q6IAA8)
Pfam (PF15454)		Homo sapiens (human)Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1,Lipid raft adaptor protein p18,Protein associated with DRMs and endosomes,p27Kip1-releasing factor from RhoA,p27RF-Rho
4D
(D)		Ragulator complex protein LAMTOR2polymer12713645.61UniProt (Q9Y2Q5)
Pfam (PF03259)		Homo sapiens (human)Endosomal adaptor protein p14,Late endosomal/lysosomal Mp1-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2,Mitogen-activated protein-binding protein-interacting protein,MAPBP-interacting protein,Roadblock domain-containing protein 3
5E
(E)		Ragulator complex protein LAMTOR3polymer12413637.71UniProt (Q9UHA4)
Pfam (PF08923)		Homo sapiens (human)Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3,MEK-binding partner 1,Mp1,Mitogen-activated protein kinase kinase 1-interacting protein 1,Mitogen-activated protein kinase scaffold protein 1
6F
(F)		Ragulator complex protein LAMTOR4polymer9910753.21UniProt (Q0VGL1)Homo sapiens (human)Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4
7G
(G)		Ragulator complex protein LAMTOR5polymer17318178.51UniProt (A0A0C4DGV4)
Pfam (PF16672)
UniProt (by SIFTS) (O43504)		Homo sapiens (human)Hepatitis B virus x interacting protein
8H
(H)		Glutathione S-transferase class-mu 26 kDa isozyme,Sodium-coupled neutral amino acid transporter 9 chimerapolymer35641000.71UniProt (P08515)
UniProt (Q8NBW4)
Pfam (PF02798)
Pfam (PF14497)		Homo sapiens (human)GST 26,Sj26 antigen,SjGST,Solute carrier family 38 member 9,Up-regulated in lung cancer 11
9I
(I)		Folliculin-interacting protein 2polymer1351149865.61UniProt (Q9P278)
Pfam (PF14637)
Pfam (PF14638)
Pfam (PF14636)		Homo sapiens (human)FNIP1-like protein,O6-methylguanine-induced apoptosis 1 protein
10J
(J)		Folliculinpolymer62269143.11UniProt (Q8NFG4)
Pfam (PF11704)
Pfam (PF16692)		Homo sapiens (human)BHD skin lesion fibrofolliculoma protein,Birt-Hogg-Dube syndrome protein
11K
(A)		[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphatenon-polymer444.21Chemie (CZC)
12L
(A)		BERYLLIUM TRIFLUORIDE IONnon-polymer66.01Chemie (BEF)
13M
(B)		GUANOSINE-5'-DIPHOSPHATEnon-polymer443.21Chemie (GDP)
Sequence modifications
A: 1 - 399 (UniProt: Q9HB90)
PDBExternal DatabaseDetails
Asn 181Asp 181conflict
Leu 400-expression tag
B: 1 - 313 (UniProt: Q7L523)
PDBExternal DatabaseDetails
Met -22-expression tag
Ser -21-expression tag
Trp -20-expression tag
Ser -19-expression tag
His -18-expression tag
Pro -17-expression tag
Gln -16-expression tag
Phe -15-expression tag
Glu -14-expression tag
Lys -13-expression tag
Gly -12-expression tag
Gly -11-expression tag
Phe -10-expression tag
Asp -9-expression tag
Ile -8-expression tag
Asp -7-expression tag
Tyr -6-expression tag
Lys -5-expression tag
Asp -4-expression tag
Asp -3-expression tag
Asp -2-expression tag
Asp -1-expression tag
Lys 0-expression tag
C: 1 - 161 (UniProt: Q6IAA8)
PDBExternal DatabaseDetails
Ser -4-expression tag
Asn -3-expression tag
Ala -2-expression tag
Glu -1-expression tag
Phe 0-expression tag
Ala 2Gly 2engineered mutation
D: 1 - 125 (UniProt: Q9Y2Q5)
PDBExternal DatabaseDetails
Gly -1-expression tag
Ala 0-expression tag
H: -234 - -18 (UniProt: P08515)
PDBExternal DatabaseDetails
Met -236-initiating methionine
Ala -235-expression tag
Ser -17-linker
Asp -16-linker
Asp -15-linker
Tyr -14-linker
Asp -13-linker
Ile -12-linker
Pro -11-linker
Thr -10-linker
Thr -9-linker
Glu -8-linker
Asn -7-linker
Leu -6-linker
Tyr -5-linker
Phe -4-linker
Gln -3-linker
Gly -2-linker
Gly -1-linker
Thr 0-linker
H: 1 - 119 (UniProt: Q8NBW4)
I: 1 - 1114 (UniProt: Q9P278)
PDBExternal DatabaseDetails
Met -236-initiating methionine
Ala -235-expression tag
Ser -234-expression tag
Pro -233-expression tag
Ile -232-expression tag
Leu -231-expression tag
Gly -230-expression tag
Tyr -229-expression tag
Trp -228-expression tag
Lys -227-expression tag
Ile -226-expression tag
Lys -225-expression tag
Gly -224-expression tag
Leu -223-expression tag
Val -222-expression tag
Gln -221-expression tag
Pro -220-expression tag
Thr -219-expression tag
Arg -218-expression tag
Leu -217-expression tag
Leu -216-expression tag
Leu -215-expression tag
Glu -214-expression tag
Tyr -213-expression tag
Leu -212-expression tag
Glu -211-expression tag
Glu -210-expression tag
Lys -209-expression tag
Tyr -208-expression tag
Glu -207-expression tag
Glu -206-expression tag
His -205-expression tag
Leu -204-expression tag
Tyr -203-expression tag
Glu -202-expression tag
Arg -201-expression tag
Asp -200-expression tag
Glu -199-expression tag
Gly -198-expression tag
Asp -197-expression tag
Lys -196-expression tag
Trp -195-expression tag
Arg -194-expression tag
Asn -193-expression tag
Lys -192-expression tag
Lys -191-expression tag
Phe -190-expression tag
Glu -189-expression tag
Leu -188-expression tag
Gly -187-expression tag
Leu -186-expression tag
Glu -185-expression tag
Phe -184-expression tag
Pro -183-expression tag
Asn -182-expression tag
Leu -181-expression tag
Pro -180-expression tag
Tyr -179-expression tag
Tyr -178-expression tag
Ile -177-expression tag
Asp -176-expression tag
Gly -175-expression tag
Asp -174-expression tag
Val -173-expression tag
Lys -172-expression tag
Leu -171-expression tag
Thr -170-expression tag
Gln -169-expression tag
Ser -168-expression tag
Met -167-expression tag
Ala -166-expression tag
Ile -165-expression tag
Ile -164-expression tag
Arg -163-expression tag
Tyr -162-expression tag
Ile -161-expression tag
Ala -160-expression tag
Asp -159-expression tag
Lys -158-expression tag
His -157-expression tag
Asn -156-expression tag
Met -155-expression tag
Leu -154-expression tag
Gly -153-expression tag
Gly -152-expression tag
Cys -151-expression tag
Pro -150-expression tag
Lys -149-expression tag
Glu -148-expression tag
Arg -147-expression tag
Ala -146-expression tag
Glu -145-expression tag
Ile -144-expression tag
Ser -143-expression tag
Met -142-expression tag
Leu -141-expression tag
Glu -140-expression tag
Gly -139-expression tag
Ala -138-expression tag
Val -137-expression tag
Leu -136-expression tag
Asp -135-expression tag
Ile -134-expression tag
Arg -133-expression tag
Tyr -132-expression tag
Gly -131-expression tag
Val -130-expression tag
Ser -129-expression tag
Arg -128-expression tag
Ile -127-expression tag
Ala -126-expression tag
Tyr -125-expression tag
Ser -124-expression tag
Lys -123-expression tag
Asp -122-expression tag
Phe -121-expression tag
Glu -120-expression tag
Thr -119-expression tag
Leu -118-expression tag
Lys -117-expression tag
Val -116-expression tag
Asp -115-expression tag
Phe -114-expression tag
Leu -113-expression tag
Ser -112-expression tag
Lys -111-expression tag
Leu -110-expression tag
Pro -109-expression tag
Glu -108-expression tag
Met -107-expression tag
Leu -106-expression tag
Lys -105-expression tag
Met -104-expression tag
Phe -103-expression tag
Glu -102-expression tag
Asp -101-expression tag
Arg -100-expression tag
Leu -99-expression tag
Cys -98-expression tag
His -97-expression tag
Lys -96-expression tag
Thr -95-expression tag
Tyr -94-expression tag
Leu -93-expression tag
Asn -92-expression tag
Gly -91-expression tag
Asp -90-expression tag
His -89-expression tag
Val -88-expression tag
Thr -87-expression tag
His -86-expression tag
Pro -85-expression tag
Asp -84-expression tag
Phe -83-expression tag
Met -82-expression tag
Leu -81-expression tag
Tyr -80-expression tag
Asp -79-expression tag
Ala -78-expression tag
Leu -77-expression tag
Asp -76-expression tag
Val -75-expression tag
Val -74-expression tag
Leu -73-expression tag
Tyr -72-expression tag
Met -71-expression tag
Asp -70-expression tag
Pro -69-expression tag
Met -68-expression tag
Cys -67-expression tag
Leu -66-expression tag
Asp -65-expression tag
Ala -64-expression tag
Phe -63-expression tag
Pro -62-expression tag
Lys -61-expression tag
Leu -60-expression tag
Val -59-expression tag
Cys -58-expression tag
Phe -57-expression tag
Lys -56-expression tag
Lys -55-expression tag
Arg -54-expression tag
Ile -53-expression tag
Glu -52-expression tag
Ala -51-expression tag
Ile -50-expression tag
Pro -49-expression tag
Gln -48-expression tag
Ile -47-expression tag
Asp -46-expression tag
Lys -45-expression tag
Tyr -44-expression tag
Leu -43-expression tag
Lys -42-expression tag
Ser -41-expression tag
Ser -40-expression tag
Lys -39-expression tag
Tyr -38-expression tag
Ile -37-expression tag
Ala -36-expression tag
Trp -35-expression tag
Pro -34-expression tag
Leu -33-expression tag
Gln -32-expression tag
Gly -31-expression tag
Trp -30-expression tag
Gln -29-expression tag
Ala -28-expression tag
Thr -27-expression tag
Phe -26-expression tag
Gly -25-expression tag
Gly -24-expression tag
Gly -23-expression tag
Asp -22-expression tag
His -21-expression tag
Pro -20-expression tag
Pro -19-expression tag
Lys -18-expression tag
Ser -17-expression tag
Asp -16-expression tag
Asp -15-expression tag
Tyr -14-expression tag
Asp -13-expression tag
Ile -12-expression tag
Pro -11-expression tag
Thr -10-expression tag
Thr -9-expression tag
Glu -8-expression tag
Asn -7-expression tag
Leu -6-expression tag
Tyr -5-expression tag
Phe -4-expression tag
Gln -3-expression tag
Gly -2-expression tag
Gly -1-expression tag
Thr 0-expression tag
J: 1 - 579 (UniProt: Q8NFG4)
PDBExternal DatabaseDetails
Met -42-initiating methionine
Ala -41-expression tag
Ser -40-expression tag
Trp -39-expression tag
Ser -38-expression tag
His -37-expression tag
Pro -36-expression tag
Gln -35-expression tag
Phe -34-expression tag
Glu -33-expression tag
Lys -32-expression tag
Gly -31-expression tag
Gly -30-expression tag
Gly -29-expression tag
Ala -28-expression tag
Arg -27-expression tag
Gly -26-expression tag
Gly -25-expression tag
Ser -24-expression tag
Gly -23-expression tag
Gly -22-expression tag
Gly -21-expression tag
Ser -20-expression tag
Trp -19-expression tag
Ser -18-expression tag
His -17-expression tag
Pro -16-expression tag
Gln -15-expression tag
Phe -14-expression tag
Glu -13-expression tag
Lys -12-expression tag
Gly -11-expression tag
Phe -10-expression tag
Asp -9-expression tag
Tyr -8-expression tag
Lys -7-expression tag
Asp -6-expression tag
Asp -5-expression tag
Asp -4-expression tag
Asp -3-expression tag
Lys -2-expression tag
Gly -1-expression tag
Thr 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains10
Total formula weight418295.9
Non-Polymers*Number of molecules3
Total formula weight953.4
All*Total formula weight419249.3
*Water molecules are not included.

246905

PDB entries from 2025-12-31

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