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8DHB

Active FLCN GAP complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005829cellular_componentcytosol
A0006351biological_processDNA-templated transcription
A0006915biological_processapoptotic process
A0007264biological_processsmall GTPase-mediated signal transduction
A0008104biological_processprotein localization
A0008380biological_processRNA splicing
A0009267biological_processcellular response to starvation
A0010507biological_processnegative regulation of autophagy
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0031669biological_processcellular response to nutrient levels
A0032006biological_processregulation of TOR signaling
A0034198biological_processcellular response to amino acid starvation
A0043200biological_processresponse to amino acid
A0043231cellular_componentintracellular membrane-bounded organelle
A0043495molecular_functionprotein-membrane adaptor activity
A0046982molecular_functionprotein heterodimerization activity
A0051020molecular_functionGTPase binding
A0060090molecular_functionmolecular adaptor activity
A0061462biological_processprotein localization to lysosome
A0071230biological_processcellular response to amino acid stimulus
A0072657biological_processprotein localization to membrane
A0140767molecular_functionenzyme-substrate adaptor activity
A1903432biological_processregulation of TORC1 signaling
A1904263biological_processpositive regulation of TORC1 signaling
A1990131cellular_componentGtr1-Gtr2 GTPase complex
A1990877cellular_componentFNIP-folliculin RagC/D GAP
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0006915biological_processapoptotic process
B0008104biological_processprotein localization
B0009267biological_processcellular response to starvation
B0010507biological_processnegative regulation of autophagy
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0031625molecular_functionubiquitin protein ligase binding
B0031669biological_processcellular response to nutrient levels
B0032008biological_processpositive regulation of TOR signaling
B0033209biological_processtumor necrosis factor-mediated signaling pathway
B0034198biological_processcellular response to amino acid starvation
B0035556biological_processintracellular signal transduction
B0042593biological_processglucose homeostasis
B0042803molecular_functionprotein homodimerization activity
B0043495molecular_functionprotein-membrane adaptor activity
B0046982molecular_functionprotein heterodimerization activity
B0051219molecular_functionphosphoprotein binding
B0061462biological_processprotein localization to lysosome
B0071230biological_processcellular response to amino acid stimulus
B0072657biological_processprotein localization to membrane
B1904263biological_processpositive regulation of TORC1 signaling
B1990130cellular_componentGATOR1 complex
B1990131cellular_componentGtr1-Gtr2 GTPase complex
B1990877cellular_componentFNIP-folliculin RagC/D GAP
C0001558biological_processregulation of cell growth
C0001919biological_processregulation of receptor recycling
C0005085molecular_functionguanyl-nucleotide exchange factor activity
C0005515molecular_functionprotein binding
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005768cellular_componentendosome
C0005886cellular_componentplasma membrane
C0007032biological_processendosome organization
C0007040biological_processlysosome organization
C0008104biological_processprotein localization
C0010874biological_processregulation of cholesterol efflux
C0016020cellular_componentmembrane
C0016197biological_processendosomal transport
C0031669biological_processcellular response to nutrient levels
C0031902cellular_componentlate endosome membrane
C0032008biological_processpositive regulation of TOR signaling
C0032418biological_processlysosome localization
C0035577cellular_componentazurophil granule membrane
C0035579cellular_componentspecific granule membrane
C0038202biological_processTORC1 signaling
C0042632biological_processcholesterol homeostasis
C0043410biological_processpositive regulation of MAPK cascade
C0043495molecular_functionprotein-membrane adaptor activity
C0045121cellular_componentmembrane raft
C0051020molecular_functionGTPase binding
C0060090molecular_functionmolecular adaptor activity
C0060620biological_processregulation of cholesterol import
C0070062cellular_componentextracellular exosome
C0071230biological_processcellular response to amino acid stimulus
C0071986cellular_componentRagulator complex
C0072657biological_processprotein localization to membrane
C0101003cellular_componentficolin-1-rich granule membrane
C0150032biological_processpositive regulation of protein localization to lysosome
C1904263biological_processpositive regulation of TORC1 signaling
C1990877cellular_componentFNIP-folliculin RagC/D GAP
D0001558biological_processregulation of cell growth
D0005085molecular_functionguanyl-nucleotide exchange factor activity
D0005515molecular_functionprotein binding
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0005768cellular_componentendosome
D0005770cellular_componentlate endosome
D0005886cellular_componentplasma membrane
D0008104biological_processprotein localization
D0010008cellular_componentendosome membrane
D0010761biological_processfibroblast migration
D0016020cellular_componentmembrane
D0031902cellular_componentlate endosome membrane
D0032008biological_processpositive regulation of TOR signaling
D0035579cellular_componentspecific granule membrane
D0038202biological_processTORC1 signaling
D0043410biological_processpositive regulation of MAPK cascade
D0060090molecular_functionmolecular adaptor activity
D0070821cellular_componenttertiary granule membrane
D0071230biological_processcellular response to amino acid stimulus
D0071986cellular_componentRagulator complex
D0150116biological_processregulation of cell-substrate junction organization
D1902414biological_processprotein localization to cell junction
D1904263biological_processpositive regulation of TORC1 signaling
D1990877cellular_componentFNIP-folliculin RagC/D GAP
E0005085molecular_functionguanyl-nucleotide exchange factor activity
E0005515molecular_functionprotein binding
E0005765cellular_componentlysosomal membrane
E0005768cellular_componentendosome
E0005770cellular_componentlate endosome
E0005886cellular_componentplasma membrane
E0005925cellular_componentfocal adhesion
E0008104biological_processprotein localization
E0010008cellular_componentendosome membrane
E0016020cellular_componentmembrane
E0019209molecular_functionkinase activator activity
E0031902cellular_componentlate endosome membrane
E0032006biological_processregulation of TOR signaling
E0032008biological_processpositive regulation of TOR signaling
E0035579cellular_componentspecific granule membrane
E0038202biological_processTORC1 signaling
E0043410biological_processpositive regulation of MAPK cascade
E0060090molecular_functionmolecular adaptor activity
E0070062cellular_componentextracellular exosome
E0070821cellular_componenttertiary granule membrane
E0071230biological_processcellular response to amino acid stimulus
E0071986cellular_componentRagulator complex
E1902414biological_processprotein localization to cell junction
E1904263biological_processpositive regulation of TORC1 signaling
E1990877cellular_componentFNIP-folliculin RagC/D GAP
F0005085molecular_functionguanyl-nucleotide exchange factor activity
F0005515molecular_functionprotein binding
F0005764cellular_componentlysosome
F0005765cellular_componentlysosomal membrane
F0008361biological_processregulation of cell size
F0031902cellular_componentlate endosome membrane
F0032008biological_processpositive regulation of TOR signaling
F0038202biological_processTORC1 signaling
F0043231cellular_componentintracellular membrane-bounded organelle
F0060090molecular_functionmolecular adaptor activity
F0061462biological_processprotein localization to lysosome
F0071230biological_processcellular response to amino acid stimulus
F0071986cellular_componentRagulator complex
F1904263biological_processpositive regulation of TORC1 signaling
F1990877cellular_componentFNIP-folliculin RagC/D GAP
G0005085molecular_functionguanyl-nucleotide exchange factor activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005764cellular_componentlysosome
G0005765cellular_componentlysosomal membrane
G0005829cellular_componentcytosol
G0008361biological_processregulation of cell size
G0009615biological_processresponse to virus
G0010628biological_processpositive regulation of gene expression
G0019079biological_processviral genome replication
G0031902cellular_componentlate endosome membrane
G0032008biological_processpositive regulation of TOR signaling
G0032757biological_processpositive regulation of interleukin-8 production
G0032991cellular_componentprotein-containing complex
G0038202biological_processTORC1 signaling
G0043066biological_processnegative regulation of apoptotic process
G0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
G0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
G0051092biological_processpositive regulation of NF-kappaB transcription factor activity
G0060090molecular_functionmolecular adaptor activity
G0061462biological_processprotein localization to lysosome
G0071230biological_processcellular response to amino acid stimulus
G0071986cellular_componentRagulator complex
G1900182biological_processpositive regulation of protein localization to nucleus
G1904263biological_processpositive regulation of TORC1 signaling
G1905636biological_processpositive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
G1990877cellular_componentFNIP-folliculin RagC/D GAP
H0004364molecular_functionglutathione transferase activity
H0006749biological_processglutathione metabolic process
H0016740molecular_functiontransferase activity
I0000122biological_processnegative regulation of transcription by RNA polymerase II
I0001932biological_processregulation of protein phosphorylation
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005764cellular_componentlysosome
I0005765cellular_componentlysosomal membrane
I0005829cellular_componentcytosol
I0006468biological_processprotein phosphorylation
I0006974biological_processDNA damage response
I0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
I0016020cellular_componentmembrane
I0031334biological_processpositive regulation of protein-containing complex assembly
I0033138biological_processpositive regulation of peptidyl-serine phosphorylation
I0034451cellular_componentcentriolar satellite
I0042030molecular_functionATPase inhibitor activity
I0051087molecular_functionprotein-folding chaperone binding
I1904263biological_processpositive regulation of TORC1 signaling
I1990877cellular_componentFNIP-folliculin RagC/D GAP
J0000122biological_processnegative regulation of transcription by RNA polymerase II
J0001701biological_processin utero embryonic development
J0004857molecular_functionenzyme inhibitor activity
J0005096molecular_functionGTPase activator activity
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005737cellular_componentcytoplasm
J0005764cellular_componentlysosome
J0005765cellular_componentlysosomal membrane
J0005813cellular_componentcentrosome
J0005819cellular_componentspindle
J0005829cellular_componentcytosol
J0005856cellular_componentcytoskeleton
J0005886cellular_componentplasma membrane
J0005929cellular_componentcilium
J0007043biological_processcell-cell junction assembly
J0007179biological_processtransforming growth factor beta receptor signaling pathway
J0008285biological_processnegative regulation of cell population proliferation
J0009267biological_processcellular response to starvation
J0010508biological_processpositive regulation of autophagy
J0016020cellular_componentmembrane
J0019899molecular_functionenzyme binding
J0030097biological_processhemopoiesis
J0030496cellular_componentmidbody
J0030511biological_processpositive regulation of transforming growth factor beta receptor signaling pathway
J0031929biological_processTOR signaling
J0032006biological_processregulation of TOR signaling
J0032007biological_processnegative regulation of TOR signaling
J0032008biological_processpositive regulation of TOR signaling
J0032418biological_processlysosome localization
J0034198biological_processcellular response to amino acid starvation
J0035024biological_processnegative regulation of Rho protein signal transduction
J0035556biological_processintracellular signal transduction
J0042995cellular_componentcell projection
J0043065biological_processpositive regulation of apoptotic process
J0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
J0044291cellular_componentcell-cell contact zone
J0044877molecular_functionprotein-containing complex binding
J0045820biological_processnegative regulation of glycolytic process
J0045892biological_processnegative regulation of DNA-templated transcription
J0046578biological_processregulation of Ras protein signal transduction
J0050673biological_processepithelial cell proliferation
J0050680biological_processnegative regulation of epithelial cell proliferation
J0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
J0070371biological_processERK1 and ERK2 cascade
J0070373biological_processnegative regulation of ERK1 and ERK2 cascade
J0072111biological_processcell proliferation involved in kidney development
J0072686cellular_componentmitotic spindle
J0097009biological_processenergy homeostasis
J0097193biological_processintrinsic apoptotic signaling pathway
J0120163biological_processnegative regulation of cold-induced thermogenesis
J1901723biological_processnegative regulation of cell proliferation involved in kidney development
J1901874biological_processnegative regulation of post-translational protein modification
J1903444biological_processnegative regulation of brown fat cell differentiation
J1904263biological_processpositive regulation of TORC1 signaling
J1905672biological_processnegative regulation of lysosome organization
J1990877cellular_componentFNIP-folliculin RagC/D GAP
J2000973biological_processregulation of pro-B cell differentiation
J2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00214
Number of Residues18
DetailsFABP Cytosolic fatty-acid binding proteins signature. KAYkVnpDmNFEvFIHKV
ChainResidueDetails
ALYS163-VAL180

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Essential for GTPase activation (GAP) activity => ECO:0000269|PubMed:31672913, ECO:0000269|PubMed:31704029
ChainResidueDetails
JARG164
ISER221
HASN-182
HGLN-169

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
JSER62
ISER726
CSER98
CSER141

site_idSWS_FT_FI3
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
JSER73
JSER302
JSER571
BILE164

site_idSWS_FT_FI4
Number of Residues3
DetailsMOD_RES: Phosphoserine; by ULK1 => ECO:0000269|PubMed:25126726
ChainResidueDetails
JSER406
JSER537
JSER542

site_idSWS_FT_FI5
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36476874
ChainResidueDetails
CLYS20
CLYS31
CLYS60

site_idSWS_FT_FI6
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q9CQ22
ChainResidueDetails
BASP130
CLYS103
CLYS104

site_idSWS_FT_FI7
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:31704029, ECO:0000269|PubMed:32868926, ECO:0007744|PDB:6ULG, ECO:0007744|PDB:6WJ2
ChainResidueDetails
BLEU148
ATHR96
AASN181

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER309

site_idSWS_FT_FI9
Number of Residues5
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25936802
ChainResidueDetails
BLYS142
BLYS220
BLYS230
BLYS244

site_idSWS_FT_FI10
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:35338845, ECO:0000269|PubMed:36697823, ECO:0007744|PDB:6U62, ECO:0007744|PDB:7T3B, ECO:0007744|PDB:7UX2, ECO:0007744|PDB:7UXC, ECO:0007744|PDB:7UXH
ChainResidueDetails
ALYS179
AILE220

site_idSWS_FT_FI11
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:35338845, ECO:0000269|PubMed:36697823, ECO:0007744|PDB:7T3B, ECO:0007744|PDB:7UX2, ECO:0007744|PDB:7UXC, ECO:0007744|PDB:7UXH
ChainResidueDetails
ASER219

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER2

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER15

site_idSWS_FT_FI14
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q99K70
ChainResidueDetails
ATHR96

222415

PDB entries from 2024-07-10

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