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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8DHB

Active FLCN GAP complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005829cellular_componentcytosol
A0006351biological_processDNA-templated transcription
A0006915biological_processapoptotic process
A0007264biological_processsmall GTPase-mediated signal transduction
A0008104biological_processintracellular protein localization
A0008380biological_processRNA splicing
A0009267biological_processcellular response to starvation
A0010507biological_processnegative regulation of autophagy
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0031669biological_processcellular response to nutrient levels
A0032006biological_processregulation of TOR signaling
A0034198biological_processcellular response to amino acid starvation
A0043200biological_processresponse to amino acid
A0043495molecular_functionprotein-membrane adaptor activity
A0046982molecular_functionprotein heterodimerization activity
A0051020molecular_functionGTPase binding
A0060090molecular_functionmolecular adaptor activity
A0061462biological_processprotein localization to lysosome
A0071230biological_processcellular response to amino acid stimulus
A0072657biological_processprotein localization to membrane
A0140767molecular_functionenzyme-substrate adaptor activity
A1903432biological_processregulation of TORC1 signaling
A1904263biological_processpositive regulation of TORC1 signaling
A1990131cellular_componentGtr1-Gtr2 GTPase complex
A1990877cellular_componentFNIP-folliculin RagC/D GAP
B0000166molecular_functionnucleotide binding
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0006915biological_processapoptotic process
B0008104biological_processintracellular protein localization
B0009267biological_processcellular response to starvation
B0010507biological_processnegative regulation of autophagy
B0016787molecular_functionhydrolase activity
B0031625molecular_functionubiquitin protein ligase binding
B0031669biological_processcellular response to nutrient levels
B0032008biological_processpositive regulation of TOR signaling
B0033209biological_processtumor necrosis factor-mediated signaling pathway
B0034198biological_processcellular response to amino acid starvation
B0035556biological_processintracellular signal transduction
B0042593biological_processglucose homeostasis
B0042803molecular_functionprotein homodimerization activity
B0043495molecular_functionprotein-membrane adaptor activity
B0046982molecular_functionprotein heterodimerization activity
B0051219molecular_functionphosphoprotein binding
B0061462biological_processprotein localization to lysosome
B0071230biological_processcellular response to amino acid stimulus
B0072657biological_processprotein localization to membrane
B1904263biological_processpositive regulation of TORC1 signaling
B1990130cellular_componentGATOR1 complex
B1990131cellular_componentGtr1-Gtr2 GTPase complex
B1990877cellular_componentFNIP-folliculin RagC/D GAP
C0001558biological_processregulation of cell growth
C0001919biological_processregulation of receptor recycling
C0005085molecular_functionguanyl-nucleotide exchange factor activity
C0005515molecular_functionprotein binding
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005886cellular_componentplasma membrane
C0007032biological_processendosome organization
C0007040biological_processlysosome organization
C0008104biological_processintracellular protein localization
C0010874biological_processregulation of cholesterol efflux
C0016197biological_processendosomal transport
C0031669biological_processcellular response to nutrient levels
C0031902cellular_componentlate endosome membrane
C0032008biological_processpositive regulation of TOR signaling
C0032418biological_processlysosome localization
C0035577cellular_componentazurophil granule membrane
C0035579cellular_componentspecific granule membrane
C0038202biological_processTORC1 signaling
C0042632biological_processcholesterol homeostasis
C0043410biological_processpositive regulation of MAPK cascade
C0043495molecular_functionprotein-membrane adaptor activity
C0045121cellular_componentmembrane raft
C0051020molecular_functionGTPase binding
C0060090molecular_functionmolecular adaptor activity
C0060620biological_processregulation of cholesterol import
C0070062cellular_componentextracellular exosome
C0071230biological_processcellular response to amino acid stimulus
C0071986cellular_componentRagulator complex
C0072657biological_processprotein localization to membrane
C0101003cellular_componentficolin-1-rich granule membrane
C0150032biological_processpositive regulation of protein localization to lysosome
C1904263biological_processpositive regulation of TORC1 signaling
C1990877cellular_componentFNIP-folliculin RagC/D GAP
D0001558biological_processregulation of cell growth
D0005085molecular_functionguanyl-nucleotide exchange factor activity
D0005737cellular_componentcytoplasm
D0005765cellular_componentlysosomal membrane
D0005770cellular_componentlate endosome
D0005886cellular_componentplasma membrane
D0008104biological_processintracellular protein localization
D0010008cellular_componentendosome membrane
D0031902cellular_componentlate endosome membrane
D0032008biological_processpositive regulation of TOR signaling
D0035579cellular_componentspecific granule membrane
D0038202biological_processTORC1 signaling
D0060090molecular_functionmolecular adaptor activity
D0070821cellular_componenttertiary granule membrane
D0071230biological_processcellular response to amino acid stimulus
D0071986cellular_componentRagulator complex
D0150116biological_processregulation of cell-substrate junction organization
D1902533biological_processpositive regulation of intracellular signal transduction
D1904263biological_processpositive regulation of TORC1 signaling
D1990877cellular_componentFNIP-folliculin RagC/D GAP
E0005085molecular_functionguanyl-nucleotide exchange factor activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005765cellular_componentlysosomal membrane
E0005770cellular_componentlate endosome
E0005886cellular_componentplasma membrane
E0005925cellular_componentfocal adhesion
E0008104biological_processintracellular protein localization
E0010008cellular_componentendosome membrane
E0019209molecular_functionkinase activator activity
E0031902cellular_componentlate endosome membrane
E0032006biological_processregulation of TOR signaling
E0032008biological_processpositive regulation of TOR signaling
E0035579cellular_componentspecific granule membrane
E0038202biological_processTORC1 signaling
E0060090molecular_functionmolecular adaptor activity
E0070062cellular_componentextracellular exosome
E0070821cellular_componenttertiary granule membrane
E0071230biological_processcellular response to amino acid stimulus
E0071986cellular_componentRagulator complex
E1902533biological_processpositive regulation of intracellular signal transduction
E1904263biological_processpositive regulation of TORC1 signaling
E1990877cellular_componentFNIP-folliculin RagC/D GAP
F0005085molecular_functionguanyl-nucleotide exchange factor activity
F0005515molecular_functionprotein binding
F0005764cellular_componentlysosome
F0005765cellular_componentlysosomal membrane
F0008361biological_processregulation of cell size
F0031902cellular_componentlate endosome membrane
F0032008biological_processpositive regulation of TOR signaling
F0038202biological_processTORC1 signaling
F0060090molecular_functionmolecular adaptor activity
F0061462biological_processprotein localization to lysosome
F0071230biological_processcellular response to amino acid stimulus
F0071986cellular_componentRagulator complex
F1904263biological_processpositive regulation of TORC1 signaling
F1990877cellular_componentFNIP-folliculin RagC/D GAP
G0005085molecular_functionguanyl-nucleotide exchange factor activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005764cellular_componentlysosome
G0005765cellular_componentlysosomal membrane
G0005829cellular_componentcytosol
G0008361biological_processregulation of cell size
G0009615biological_processresponse to virus
G0010628biological_processpositive regulation of gene expression
G0019079biological_processviral genome replication
G0031902cellular_componentlate endosome membrane
G0032008biological_processpositive regulation of TOR signaling
G0032757biological_processpositive regulation of interleukin-8 production
G0032991cellular_componentprotein-containing complex
G0038202biological_processTORC1 signaling
G0043066biological_processnegative regulation of apoptotic process
G0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
G0060090molecular_functionmolecular adaptor activity
G0061462biological_processprotein localization to lysosome
G0071230biological_processcellular response to amino acid stimulus
G0071986cellular_componentRagulator complex
G1900182biological_processpositive regulation of protein localization to nucleus
G1904263biological_processpositive regulation of TORC1 signaling
G1990877cellular_componentFNIP-folliculin RagC/D GAP
H0004364molecular_functionglutathione transferase activity
H0006749biological_processglutathione metabolic process
H0016740molecular_functiontransferase activity
I0000122biological_processnegative regulation of transcription by RNA polymerase II
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005765cellular_componentlysosomal membrane
I0005829cellular_componentcytosol
I0006974biological_processDNA damage response
I0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
I0031334biological_processpositive regulation of protein-containing complex assembly
I0032007biological_processnegative regulation of TOR signaling
I0034451cellular_componentcentriolar satellite
I0042030molecular_functionATPase inhibitor activity
I0051087molecular_functionprotein-folding chaperone binding
I1904263biological_processpositive regulation of TORC1 signaling
I1990877cellular_componentFNIP-folliculin RagC/D GAP
J0000122biological_processnegative regulation of transcription by RNA polymerase II
J0001701biological_processin utero embryonic development
J0004857molecular_functionenzyme inhibitor activity
J0005096molecular_functionGTPase activator activity
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005737cellular_componentcytoplasm
J0005764cellular_componentlysosome
J0005765cellular_componentlysosomal membrane
J0005813cellular_componentcentrosome
J0005819cellular_componentspindle
J0005829cellular_componentcytosol
J0005929cellular_componentcilium
J0007043biological_processcell-cell junction assembly
J0009267biological_processcellular response to starvation
J0010508biological_processpositive regulation of autophagy
J0019899molecular_functionenzyme binding
J0030097biological_processhemopoiesis
J0030496cellular_componentmidbody
J0030511biological_processpositive regulation of transforming growth factor beta receptor signaling pathway
J0032006biological_processregulation of TOR signaling
J0032007biological_processnegative regulation of TOR signaling
J0032008biological_processpositive regulation of TOR signaling
J0032418biological_processlysosome localization
J0034198biological_processcellular response to amino acid starvation
J0035024biological_processnegative regulation of Rho protein signal transduction
J0035556biological_processintracellular signal transduction
J0043065biological_processpositive regulation of apoptotic process
J0044291cellular_componentcell-cell contact zone
J0044877molecular_functionprotein-containing complex binding
J0045820biological_processnegative regulation of glycolytic process
J0045892biological_processnegative regulation of DNA-templated transcription
J0046578biological_processregulation of Ras protein signal transduction
J0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
J0070373biological_processnegative regulation of ERK1 and ERK2 cascade
J0072686cellular_componentmitotic spindle
J0097009biological_processenergy homeostasis
J0120163biological_processnegative regulation of cold-induced thermogenesis
J1901723biological_processnegative regulation of cell proliferation involved in kidney development
J1901874biological_processnegative regulation of post-translational protein modification
J1902532biological_processnegative regulation of intracellular signal transduction
J1903444biological_processnegative regulation of brown fat cell differentiation
J1904263biological_processpositive regulation of TORC1 signaling
J1905672biological_processnegative regulation of lysosome organization
J1990877cellular_componentFNIP-folliculin RagC/D GAP
J2000973biological_processregulation of pro-B cell differentiation
Functional Information from PROSITE/UniProt
site_idPS00214
Number of Residues18
DetailsFABP Cytosolic fatty-acid binding proteins signature. KAYkVnpDmNFEvFIHKV
ChainResidueDetails
ALYS163-VAL180
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q99K70","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36103527","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DHB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31672913","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31704029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ULG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31704029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ULG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues5
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"25936802","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36476874","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues3
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q9CQ22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues13
DetailsRegion: {"description":"Required for interaction with LAMTOR2","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"31314152","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues1
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues1
DetailsSite: {"description":"Essential for GTPase activation (GAP) activity","evidences":[{"source":"PubMed","id":"31672913","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31704029","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine; by ULK1","evidences":[{"source":"PubMed","id":"25126726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246905

PDB entries from 2025-12-31

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