8DD5
Crystal structure of KAT6A in complex with inhibitor CTx-648 (PF-9363)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone acetyltransferase KAT6A | polymer | 286 | 33731.2 | 1 | UniProt (Q92794) Pfam (PF17772) Pfam (PF01853) | Homo sapiens (human) | MOZ,YBF2/SAS3,SAS2 and TIP60 protein 3,MYST-3,Monocytic leukemia zinc finger protein,Runt-related transcription factor-binding protein 2,Zinc finger protein 220 |
| 2 | B (A) | 2,6-dimethoxy-N-{4-methoxy-6-[(1H-pyrazol-1-yl)methyl]-1,2-benzoxazol-3-yl}benzene-1-sulfonamide | non-polymer | 444.5 | 1 | Chemie (R7L) | |||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 501 - 784 (UniProt: Q92794)
| PDB | External Database | Details |
|---|---|---|
| Gly 499 | - | expression tag |
| Ser 500 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33731.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 509.9 | |
| All* | Total formula weight | 34241.1 |
