8DD5

Crystal structure of KAT6A in complex with inhibitor CTx-648 (PF-9363)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	ZN_FING: C2HC MYST-type => ECO:0000255|PROSITE-ProRule:PRU01063

Chain	Residue	Details
A	LEU537-TRP562

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:Q9H7Z6

Chain	Residue	Details
A	GLU680

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site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|Ref.27

Chain	Residue	Details
A	SER645
A	GLN654
A	SER684

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|Ref.27

Chain	Residue	Details
A	ALY604

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