8DC7
Crystal structure of p53 Y220C covalently bound to indole KG10
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cellular tumor antigen p53 | polymer | 222 | 24753.9 | 1 | UniProt (P04637) Pfam (PF00870) | Homo sapiens (human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 2 | B, C, D (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | E (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | F, G (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | H (A) | 4-[4-(4-methylpiperazin-1-yl)phenyl]-1-(2-methylprop-2-enoyl)-1H-indole-3-carbaldehyde, bound form | non-polymer | 389.5 | 1 | Chemie (R4R) | |||
| 6 | I (A) | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
A: 94 - 312 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Gly 91 | - | expression tag |
| Ser 92 | - | expression tag |
| Met 93 | - | expression tag |
| Ser 124 | Cys 124 | conflict |
| Leu 133 | Met 133 | conflict |
| Ser 182 | Cys 182 | conflict |
| Cys 220 | Tyr 220 | engineered mutation |
| Ser 229 | Cys 229 | conflict |
| Tyr 239 | Asn 239 | conflict |
| Asp 268 | Asn 268 | conflict |
| Ser 275 | Cys 275 | conflict |
| Ser 277 | Cys 277 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 24753.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 791.7 | |
| All* | Total formula weight | 25545.6 |
