8D82
Cryo-EM structure of human IL-6 signaling complex in detergent: model containing full extracellular domains
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (C, G) | Soluble interleukin-6 receptor subunit alpha | polymer | 346 | 38694.3 | 2 | UniProt (P08887) Pfam (PF00047) Pfam (PF09240) | Homo sapiens (human) | sIL6R |
| 2 | B, E (D, H) | Interleukin-6 | polymer | 183 | 20837.8 | 2 | UniProt (P05231) Pfam (PF00489) | Homo sapiens (human) | IL-6,B-cell stimulatory factor 2,BSF-2,CTL differentiation factor,CDF,Hybridoma growth factor,Interferon beta-2,IFN-beta-2 |
| 3 | C, F (A, E) | Interleukin-6 receptor subunit beta | polymer | 678 | 77085.1 | 2 | UniProt (P40189) Pfam (PF06328) Pfam (PF09240) Pfam (PF00041) | Homo sapiens (human) | IL-6 receptor subunit beta,IL-6R subunit beta,IL-6R-beta,IL-6RB,CDw130,Interleukin-6 signal transducer,Membrane glycoprotein 130,gp130,Oncostatin-M receptor subunit alpha |
| 4 | G, H, I, J, K... (B, F, I, J, K...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 10 | In PDB GlyTouCan (G42666HT) | |||
| 5 | AA, BA, CA, DA, EA... (G, E, C, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 18 | Chemie (NAG) |
Sequence modifications
C, G: 20 - 331 (UniProt: P08887)
| PDB | External Database | Details |
|---|---|---|
| Gly 332 | - | expression tag |
| Pro 333 | - | expression tag |
| Gly 334 | - | expression tag |
| Gly 335 | - | expression tag |
| Glu 336 | - | expression tag |
| Gln 337 | - | expression tag |
| Lys 338 | - | expression tag |
| Leu 339 | - | expression tag |
| Ile 340 | - | expression tag |
| Ser 341 | - | expression tag |
| Glu 342 | - | expression tag |
| Glu 343 | - | expression tag |
| Asp 344 | - | expression tag |
| Leu 345 | - | expression tag |
| Gly 346 | - | expression tag |
| Gly 347 | - | expression tag |
| Glu 348 | - | expression tag |
| Gln 349 | - | expression tag |
| Lys 350 | - | expression tag |
| Leu 351 | - | expression tag |
| Ile 352 | - | expression tag |
| Ser 353 | - | expression tag |
| Glu 354 | - | expression tag |
| Glu 355 | - | expression tag |
| Asp 356 | - | expression tag |
| Leu 357 | - | expression tag |
| Ser 358 | - | expression tag |
| Gly 359 | - | expression tag |
| His 360 | - | expression tag |
| His 361 | - | expression tag |
| His 362 | - | expression tag |
| His 363 | - | expression tag |
| His 364 | - | expression tag |
| His 365 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 273234.4 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 4244.0 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3981.7 | |
| All* | Total formula weight | 281460.2 |
