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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8D82

Cryo-EM structure of human IL-6 signaling complex in detergent: model containing full extracellular domains

Functional Information from GO Data
ChainGOidnamespacecontents
A0004896molecular_functioncytokine receptor activity
A0016020cellular_componentmembrane
C0004896molecular_functioncytokine receptor activity
C0016020cellular_componentmembrane
D0001781biological_processneutrophil apoptotic process
D0002314biological_processgerminal center B cell differentiation
D0002384biological_processhepatic immune response
D0002446biological_processneutrophil mediated immunity
D0002548biological_processmonocyte chemotaxis
D0002639biological_processpositive regulation of immunoglobulin production
D0002675biological_processpositive regulation of acute inflammatory response
D0002690biological_processpositive regulation of leukocyte chemotaxis
D0005125molecular_functioncytokine activity
D0005138molecular_functioninterleukin-6 receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005788cellular_componentendoplasmic reticulum lumen
D0005896cellular_componentinterleukin-6 receptor complex
D0006953biological_processacute-phase response
D0006954biological_processinflammatory response
D0006955biological_processimmune response
D0006959biological_processhumoral immune response
D0007259biological_processcell surface receptor signaling pathway via JAK-STAT
D0008083molecular_functiongrowth factor activity
D0008284biological_processpositive regulation of cell population proliferation
D0008285biological_processnegative regulation of cell population proliferation
D0010573biological_processvascular endothelial growth factor production
D0010574biological_processregulation of vascular endothelial growth factor production
D0010575biological_processpositive regulation of vascular endothelial growth factor production
D0010628biological_processpositive regulation of gene expression
D0010718biological_processpositive regulation of epithelial to mesenchymal transition
D0010888biological_processnegative regulation of lipid storage
D0014823biological_processresponse to activity
D0019221biological_processcytokine-mediated signaling pathway
D0030154biological_processcell differentiation
D0030168biological_processplatelet activation
D0031018biological_processendocrine pancreas development
D0031175biological_processneuron projection development
D0032494biological_processresponse to peptidoglycan
D0032682biological_processnegative regulation of chemokine production
D0032722biological_processpositive regulation of chemokine production
D0032731biological_processpositive regulation of interleukin-1 beta production
D0032733biological_processpositive regulation of interleukin-10 production
D0032740biological_processpositive regulation of interleukin-17 production
D0032745biological_processpositive regulation of interleukin-21 production
D0032755biological_processpositive regulation of interleukin-6 production
D0032757biological_processpositive regulation of interleukin-8 production
D0032760biological_processpositive regulation of tumor necrosis factor production
D0032966biological_processnegative regulation of collagen biosynthetic process
D0033138biological_processpositive regulation of peptidyl-serine phosphorylation
D0035633biological_processmaintenance of blood-brain barrier
D0042102biological_processpositive regulation of T cell proliferation
D0042593biological_processglucose homeostasis
D0042802molecular_functionidentical protein binding
D0043065biological_processpositive regulation of apoptotic process
D0043066biological_processnegative regulation of apoptotic process
D0043410biological_processpositive regulation of MAPK cascade
D0045599biological_processnegative regulation of fat cell differentiation
D0045669biological_processpositive regulation of osteoblast differentiation
D0045727biological_processpositive regulation of translation
D0045765biological_processregulation of angiogenesis
D0045779biological_processnegative regulation of bone resorption
D0045893biological_processpositive regulation of DNA-templated transcription
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
D0048661biological_processpositive regulation of smooth muscle cell proliferation
D0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
D0050768biological_processnegative regulation of neurogenesis
D0050796biological_processregulation of insulin secretion
D0050829biological_processdefense response to Gram-negative bacterium
D0050830biological_processdefense response to Gram-positive bacterium
D0050871biological_processpositive regulation of B cell activation
D0051223biological_processregulation of protein transport
D0051251biological_processpositive regulation of lymphocyte activation
D0051384biological_processresponse to glucocorticoid
D0051607biological_processdefense response to virus
D0060252biological_processpositive regulation of glial cell proliferation
D0061470biological_processT follicular helper cell differentiation
D0061888biological_processregulation of astrocyte activation
D0070050biological_processneuron cellular homeostasis
D0070091biological_processglucagon secretion
D0070092biological_processregulation of glucagon secretion
D0070102biological_processinterleukin-6-mediated signaling pathway
D0070301biological_processcellular response to hydrogen peroxide
D0071222biological_processcellular response to lipopolysaccharide
D0072540biological_processT-helper 17 cell lineage commitment
D0072574biological_processhepatocyte proliferation
D0090091biological_processpositive regulation of extracellular matrix disassembly
D0090594biological_processinflammatory response to wounding
D0097421biological_processliver regeneration
D0097696biological_processcell surface receptor signaling pathway via STAT
D0098586biological_processcellular response to virus
D0150077biological_processregulation of neuroinflammatory response
D0150078biological_processpositive regulation of neuroinflammatory response
D1900017biological_processpositive regulation of cytokine production involved in inflammatory response
D1901731biological_processpositive regulation of platelet aggregation
D1902512biological_processpositive regulation of apoptotic DNA fragmentation
D1902895biological_processpositive regulation of miRNA transcription
D1903978biological_processregulation of microglial cell activation
D1904894biological_processpositive regulation of receptor signaling pathway via STAT
D1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
D2000553biological_processpositive regulation of T-helper 2 cell cytokine production
D2000635biological_processnegative regulation of primary miRNA processing
D2000660biological_processnegative regulation of interleukin-1-mediated signaling pathway
D2000676biological_processpositive regulation of type B pancreatic cell apoptotic process
E0004896molecular_functioncytokine receptor activity
E0016020cellular_componentmembrane
G0004896molecular_functioncytokine receptor activity
G0016020cellular_componentmembrane
H0001781biological_processneutrophil apoptotic process
H0002314biological_processgerminal center B cell differentiation
H0002384biological_processhepatic immune response
H0002446biological_processneutrophil mediated immunity
H0002548biological_processmonocyte chemotaxis
H0002639biological_processpositive regulation of immunoglobulin production
H0002675biological_processpositive regulation of acute inflammatory response
H0002690biological_processpositive regulation of leukocyte chemotaxis
H0005125molecular_functioncytokine activity
H0005138molecular_functioninterleukin-6 receptor binding
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005615cellular_componentextracellular space
H0005788cellular_componentendoplasmic reticulum lumen
H0005896cellular_componentinterleukin-6 receptor complex
H0006953biological_processacute-phase response
H0006954biological_processinflammatory response
H0006955biological_processimmune response
H0006959biological_processhumoral immune response
H0007259biological_processcell surface receptor signaling pathway via JAK-STAT
H0008083molecular_functiongrowth factor activity
H0008284biological_processpositive regulation of cell population proliferation
H0008285biological_processnegative regulation of cell population proliferation
H0010573biological_processvascular endothelial growth factor production
H0010574biological_processregulation of vascular endothelial growth factor production
H0010575biological_processpositive regulation of vascular endothelial growth factor production
H0010628biological_processpositive regulation of gene expression
H0010718biological_processpositive regulation of epithelial to mesenchymal transition
H0010888biological_processnegative regulation of lipid storage
H0014823biological_processresponse to activity
H0019221biological_processcytokine-mediated signaling pathway
H0030154biological_processcell differentiation
H0030168biological_processplatelet activation
H0031018biological_processendocrine pancreas development
H0031175biological_processneuron projection development
H0032494biological_processresponse to peptidoglycan
H0032682biological_processnegative regulation of chemokine production
H0032722biological_processpositive regulation of chemokine production
H0032731biological_processpositive regulation of interleukin-1 beta production
H0032733biological_processpositive regulation of interleukin-10 production
H0032740biological_processpositive regulation of interleukin-17 production
H0032745biological_processpositive regulation of interleukin-21 production
H0032755biological_processpositive regulation of interleukin-6 production
H0032757biological_processpositive regulation of interleukin-8 production
H0032760biological_processpositive regulation of tumor necrosis factor production
H0032966biological_processnegative regulation of collagen biosynthetic process
H0033138biological_processpositive regulation of peptidyl-serine phosphorylation
H0035633biological_processmaintenance of blood-brain barrier
H0042102biological_processpositive regulation of T cell proliferation
H0042593biological_processglucose homeostasis
H0042802molecular_functionidentical protein binding
H0043065biological_processpositive regulation of apoptotic process
H0043066biological_processnegative regulation of apoptotic process
H0043410biological_processpositive regulation of MAPK cascade
H0045599biological_processnegative regulation of fat cell differentiation
H0045669biological_processpositive regulation of osteoblast differentiation
H0045727biological_processpositive regulation of translation
H0045765biological_processregulation of angiogenesis
H0045779biological_processnegative regulation of bone resorption
H0045893biological_processpositive regulation of DNA-templated transcription
H0045944biological_processpositive regulation of transcription by RNA polymerase II
H0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
H0048661biological_processpositive regulation of smooth muscle cell proliferation
H0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
H0050768biological_processnegative regulation of neurogenesis
H0050796biological_processregulation of insulin secretion
H0050829biological_processdefense response to Gram-negative bacterium
H0050830biological_processdefense response to Gram-positive bacterium
H0050871biological_processpositive regulation of B cell activation
H0051223biological_processregulation of protein transport
H0051251biological_processpositive regulation of lymphocyte activation
H0051384biological_processresponse to glucocorticoid
H0051607biological_processdefense response to virus
H0060252biological_processpositive regulation of glial cell proliferation
H0061470biological_processT follicular helper cell differentiation
H0061888biological_processregulation of astrocyte activation
H0070050biological_processneuron cellular homeostasis
H0070091biological_processglucagon secretion
H0070092biological_processregulation of glucagon secretion
H0070102biological_processinterleukin-6-mediated signaling pathway
H0070301biological_processcellular response to hydrogen peroxide
H0071222biological_processcellular response to lipopolysaccharide
H0072540biological_processT-helper 17 cell lineage commitment
H0072574biological_processhepatocyte proliferation
H0090091biological_processpositive regulation of extracellular matrix disassembly
H0090594biological_processinflammatory response to wounding
H0097421biological_processliver regeneration
H0097696biological_processcell surface receptor signaling pathway via STAT
H0098586biological_processcellular response to virus
H0150077biological_processregulation of neuroinflammatory response
H0150078biological_processpositive regulation of neuroinflammatory response
H1900017biological_processpositive regulation of cytokine production involved in inflammatory response
H1901731biological_processpositive regulation of platelet aggregation
H1902512biological_processpositive regulation of apoptotic DNA fragmentation
H1902895biological_processpositive regulation of miRNA transcription
H1903978biological_processregulation of microglial cell activation
H1904894biological_processpositive regulation of receptor signaling pathway via STAT
H1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
H2000553biological_processpositive regulation of T-helper 2 cell cytokine production
H2000635biological_processnegative regulation of primary miRNA processing
H2000660biological_processnegative regulation of interleukin-1-mediated signaling pathway
H2000676biological_processpositive regulation of type B pancreatic cell apoptotic process
Functional Information from PROSITE/UniProt
site_idPS00254
Number of Residues26
DetailsINTERLEUKIN_6 Interleukin-6 / G-CSF / MGF signature. CfqsgfneetClvkiitGLleFevyL
ChainResidueDetails
DCYS101-LEU126
site_idPS01353
Number of Residues54
DetailsHEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NlvgkSdaavltipacdfqathpvmdlkafpkdnmlw....VeWtt.Presvkk...Yi.LeW
ChainResidueDetails
AASN404-TRP457
site_idPS01354
Number of Residues42
DetailsHEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. LqPDPPanItvtavarnprwLsvtWqdPhSWnssf..YrLrFeL
ChainResidueDetails
CLEU214-LEU255
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues360
DetailsDomain: {"description":"Ig-like C2-type"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues390
DetailsDomain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues396
DetailsDomain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues16
DetailsMotif: {"description":"WSXWS motif"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsSite: {"description":"Not glycosylated","evidences":[{"source":"PubMed","id":"10066782","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10066782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28060820","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28060820","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"1883960","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues190
DetailsDomain: {"description":"Fibronectin type-III 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues182
DetailsDomain: {"description":"Fibronectin type-III 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

244349

PDB entries from 2025-11-05

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