8D81
Cereblon~DDB1 bound to Pomalidomide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA damage-binding protein 1 | polymer | 836 | 93347.1 | 1 | UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) | Homo sapiens (human) | DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe |
| 2 | B (B) | Protein cereblon | polymer | 442 | 50603.7 | 1 | UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226) | Homo sapiens (human) | |
| 3 | C (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (B) | S-Pomalidomide | non-polymer | 273.2 | 1 | Chemie (Y70) |
Sequence modifications
A: 1 - 699 (UniProt: Q16531)
A: 706 - 1140 (UniProt: Q16531)
A: 706 - 1140 (UniProt: Q16531)
| PDB | External Database | Details |
|---|---|---|
| Gly 700 | - | linker |
| Asn 701 | - | linker |
| Gly 702 | - | linker |
| Asn 703 | - | linker |
| Ser 704 | - | linker |
| Gly 705 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 143950.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 338.7 | |
| All* | Total formula weight | 144289.4 |
