8D6J
Human Ago2 bound to miR122(21nt) with PIWI loop swapped to AtAgo10 sequence
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein argonaute-2 | polymer | 859 | 97479.1 | 1 | UniProt (Q9UKV8) Pfam (PF16486) Pfam (PF08699) Pfam (PF02170) Pfam (PF16488) Pfam (PF16487) Pfam (PF02171) | Homo sapiens (human) | Argonaute2,hAgo2,Argonaute RISC catalytic component 2,Eukaryotic translation initiation factor 2C 2,eIF-2C 2,eIF2C 2,PAZ Piwi domain protein,PPD,Protein slicer |
| 2 | B (B) | RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3') | polymer | 21 | 6788.0 | 1 | Synthetic construct | ||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
A: 1 - 859 (UniProt: Q9UKV8)
| PDB | External Database | Details |
|---|---|---|
| Asp 387 | Ser 387 | conflict |
| Glu 602 | Pro 602 | conflict |
| Asn 603 | Ala 603 | conflict |
| Glu 605 | Asp 605 | conflict |
| Glu 606 | Gly 606 | conflict |
| Ser 607 | Lys 607 | conflict |
| Ser 608 | Lys 608 | conflict |
| Ala 824 | Ser 824 | conflict |
| Asp 828 | Ser 828 | conflict |
| Asp 831 | Ser 831 | conflict |
| Ala 834 | Ser 834 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 104267.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 24.3 | |
| All* | Total formula weight | 104291.4 |
