8D41

Crystal structure of the human COPB2 WD-domain in complex with OICR-6254

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Coatomer subunit beta'	polymer	318	36421.2	2	UniProt (P35606) Pfam (PF00400)	Homo sapiens (human)	Beta'-coat protein,Beta'-COP,p102
2	C, F (A, B)	(1R,2R,3S,4S)-3-[4-(4-fluorophenyl)piperazine-1-carbonyl]bicyclo[2.2.1]heptane-2-carboxylic acid	non-polymer		346.4	2	Chemie (Q93)
3	D (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	E (A)	UNKNOWN ATOM OR ION	non-polymer		75.1	1	Chemie (UNX)
5	G, H (A, B)	water	water		18.0	350	Chemie (HOH)

Sequence modifications

A, B: 1 - 300 (UniProt: P35606)

PDB	External Database	Details
Met -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Arg -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72842.4
Non-Polymers*	Number of molecules	4
	Total formula weight	860.0
All*	Total formula weight	73702.4

*Water molecules are not included.