8D3E
Crystal structure of human Apoptosis-Inducing Factor (AIF) W196A mutant complexed with 6-fluoroquinolin-4-amine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Apoptosis-inducing factor 1, mitochondrial | polymer | 543 | 59355.4 | 2 | UniProt (O95831) Pfam (PF00070) Pfam (PF14721) In PDB | Homo sapiens (human) | Programmed cell death protein 8 |
| 2 | A, B | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 2 | Chemie (FAD) | |||
| 3 | A | 6-fluoroquinolin-4-amine | non-polymer | 162.2 | 1 | Chemie (QDI) | |||
| 4 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | water | water | 18.0 | 356 | Chemie (HOH) |
Sequence modifications
A, B: 78 - 613 (UniProt: O95831)
| PDB | External Database | Details |
|---|---|---|
| Met 77 | - | initiating methionine |
| Ala 196 | Trp 196 | engineered mutation |
| Leu 614 | - | expression tag |
| Glu 615 | - | expression tag |
| Val 616 | - | expression tag |
| Leu 617 | - | expression tag |
| Phe 618 | - | expression tag |
| Gln 619 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 118710.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1892.9 | |
| All* | Total formula weight | 120603.7 |
