8CW2
Crystal structure of TDP1 complexed with compound XZ760
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosyl-DNA phosphodiesterase 1 | polymer | 461 | 52126.3 | 2 | UniProt (Q9NUW8) Pfam (PF06087) | Homo sapiens (human) | Tyr-DNA phosphodiesterase 1 |
| 2 | C, J (A, B) | 4-({(4R)-7-phenyl-2-[4-(2-{[4-(pyridin-2-yl)phenyl]methoxy}ethyl)phenyl]imidazo[1,2-a]pyridin-3-yl}amino)benzene-1,2-dicarboxylic acid | non-polymer | 660.7 | 2 | Chemie (OYR) | |||
| 3 | D (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 4 | E (A) | 3[N-MORPHOLINO]PROPANE SULFONIC ACID | non-polymer | 209.3 | 1 | Chemie (MPO) | |||
| 5 | F, G, H, I, K (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 6 | L, M (A, B) | water | water | 18.0 | 699 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 104252.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1919.2 | |
| All* | Total formula weight | 106171.8 |
