8CW2

Crystal structure of TDP1 complexed with compound XZ760

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0006281	biological_process	DNA repair
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0005634	cellular_component	nucleus
B	0006281	biological_process	DNA repair
B	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:12470949, ECO:0000269|PubMed:15111055

Chain	Residue	Details
A	HIS263
B	HIS263

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:12470949, ECO:0000269|PubMed:15111055

Chain	Residue	Details
A	HIS493
B	HIS493

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:12470949

Chain	Residue	Details
A	LYS265
A	LYS495
B	LYS265
B	LYS495

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Interaction with DNA => ECO:0000269|PubMed:12470949

Chain	Residue	Details
A	SER518
B	SER518

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	SER148
B	SER148

---