8CUH
Crystal structure of human TEAD2 complexed with its inhibitor TM2.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Transcriptional enhancer factor TEF-4 | polymer | 240 | 27489.1 | 2 | UniProt (Q15562) Pfam (PF17725) In PDB | Homo sapiens (human) | TEA domain family member 2,TEAD-2 |
2 | A, B | 4-[3-(2-cyclohexylethoxy)benzoyl]-N-phenylpiperazine-1-carboxamide | non-polymer | 435.6 | 2 | Chemie (P0I) | |||
3 | water | water | 18.0 | 30 | Chemie (HOH) |
Sequence modifications
A, B: 217 - 447 (UniProt: Q15562)
PDB | External Database | Details |
---|---|---|
Met 216 | - | expression tag |
Val 448 | - | expression tag |
Glu 449 | - | expression tag |
His 450 | - | expression tag |
His 451 | - | expression tag |
His 452 | - | expression tag |
His 453 | - | expression tag |
His 454 | - | expression tag |
His 455 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 54978.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 871.1 | |
All* | Total formula weight | 55849.3 |