8CUH

Crystal structure of human TEAD2 complexed with its inhibitor TM2.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Transcriptional enhancer factor TEF-4	polymer	240	27489.1	2	UniProt (Q15562) Pfam (PF17725)	Homo sapiens (human)	TEA domain family member 2,TEAD-2
2	C, D (A, B)	4-[3-(2-cyclohexylethoxy)benzoyl]-N-phenylpiperazine-1-carboxamide	non-polymer		435.6	2	Chemie (P0I)
3	E, F (A, B)	water	water		18.0	30	Chemie (HOH)

Sequence modifications

A, B: 217 - 447 (UniProt: Q15562)

PDB	External Database	Details
Met 216	-	expression tag
Val 448	-	expression tag
Glu 449	-	expression tag
His 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag
His 454	-	expression tag
His 455	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	54978.2
Non-Polymers*	Number of molecules	2
	Total formula weight	871.1
All*	Total formula weight	55849.3

*Water molecules are not included.