8CUB

Crystal Structure of ABCG5/G8 in Complex with Cholesterol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (C, A)	ATP-binding cassette sub-family G member 5	polymer	664	74249.1	2	UniProt (Q9H222) Pfam (PF00005) Pfam (PF19055) Pfam (PF01061)	Homo sapiens (Human)	Sterolin-1
2	B, D (D, B)	ATP-binding cassette sub-family G member 8	polymer	687	77246.2	2	UniProt (Q9H221) Pfam (PF00005) Pfam (PF19055) Pfam (PF01061)	Homo sapiens (Human)	Sterolin-2
3	E, F (C, A)	CHOLESTEROL	non-polymer		386.7	2	Chemie (CLR)

Sequence modifications

C, A: 3 - 651 (UniProt: Q9H222)

PDB	External Database	Details
Gly 652	-	expression tag
Ser 653	-	expression tag
His 654	-	expression tag
His 655	-	expression tag
His 656	-	expression tag
His 657	-	expression tag
His 658	-	expression tag
His 659	-	expression tag
Gly 660	-	expression tag
His 661	-	expression tag
His 662	-	expression tag
His 663	-	expression tag
His 664	-	expression tag
His 665	-	expression tag
His 666	-	expression tag

D, B: 2 - 673 (UniProt: Q9H221)

PDB	External Database	Details
Met -1	-	expression tag
Gly 0	-	expression tag
Ser 1	-	expression tag
Ala 674	-	expression tag
Ser 675	-	expression tag
Asn 676	-	expression tag
Ser 677	-	expression tag
Leu 678	-	expression tag
Glu 679	-	expression tag
Val 680	-	expression tag
Leu 681	-	expression tag
Phe 682	-	expression tag
Gln 683	-	expression tag
Met 684	-	expression tag
Glu 685	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	302990.6
Non-Polymers*	Number of molecules	2
	Total formula weight	773.3
All*	Total formula weight	303763.9

*Water molecules are not included.