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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8CUB

Crystal Structure of ABCG5/G8 in Complex with Cholesterol

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0006869biological_processlipid transport
A0007584biological_processresponse to nutrient
A0009410biological_processresponse to xenobiotic stimulus
A0010212biological_processresponse to ionizing radiation
A0010949biological_processnegative regulation of intestinal phytosterol absorption
A0014850biological_processresponse to muscle activity
A0015918biological_processsterol transport
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0016887molecular_functionATP hydrolysis activity
A0030299biological_processintestinal cholesterol absorption
A0031667biological_processresponse to nutrient levels
A0033344biological_processcholesterol efflux
A0042626molecular_functionATPase-coupled transmembrane transporter activity
A0042632biological_processcholesterol homeostasis
A0043190cellular_componentATP-binding cassette (ABC) transporter complex
A0043235cellular_componentreceptor complex
A0045177cellular_componentapical part of cell
A0045796biological_processnegative regulation of intestinal cholesterol absorption
A0046872molecular_functionmetal ion binding
A0046982molecular_functionprotein heterodimerization activity
A0046983molecular_functionprotein dimerization activity
A0055085biological_processtransmembrane transport
A0070328biological_processtriglyceride homeostasis
A0120020molecular_functioncholesterol transfer activity
A0140359molecular_functionABC-type transporter activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005886cellular_componentplasma membrane
B0006869biological_processlipid transport
B0007584biological_processresponse to nutrient
B0009410biological_processresponse to xenobiotic stimulus
B0010949biological_processnegative regulation of intestinal phytosterol absorption
B0014850biological_processresponse to muscle activity
B0015914biological_processphospholipid transport
B0015918biological_processsterol transport
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0016887molecular_functionATP hydrolysis activity
B0030299biological_processintestinal cholesterol absorption
B0031667biological_processresponse to nutrient levels
B0033344biological_processcholesterol efflux
B0042626molecular_functionATPase-coupled transmembrane transporter activity
B0042632biological_processcholesterol homeostasis
B0043190cellular_componentATP-binding cassette (ABC) transporter complex
B0043235cellular_componentreceptor complex
B0045796biological_processnegative regulation of intestinal cholesterol absorption
B0046872molecular_functionmetal ion binding
B0046982molecular_functionprotein heterodimerization activity
B0046983molecular_functionprotein dimerization activity
B0055085biological_processtransmembrane transport
B0055092biological_processsterol homeostasis
B0070328biological_processtriglyceride homeostasis
B0120020molecular_functioncholesterol transfer activity
B0140359molecular_functionABC-type transporter activity
C0000166molecular_functionnucleotide binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005886cellular_componentplasma membrane
C0006869biological_processlipid transport
C0007584biological_processresponse to nutrient
C0009410biological_processresponse to xenobiotic stimulus
C0010212biological_processresponse to ionizing radiation
C0010949biological_processnegative regulation of intestinal phytosterol absorption
C0014850biological_processresponse to muscle activity
C0015918biological_processsterol transport
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0016887molecular_functionATP hydrolysis activity
C0030299biological_processintestinal cholesterol absorption
C0031667biological_processresponse to nutrient levels
C0033344biological_processcholesterol efflux
C0042626molecular_functionATPase-coupled transmembrane transporter activity
C0042632biological_processcholesterol homeostasis
C0043190cellular_componentATP-binding cassette (ABC) transporter complex
C0043235cellular_componentreceptor complex
C0045177cellular_componentapical part of cell
C0045796biological_processnegative regulation of intestinal cholesterol absorption
C0046872molecular_functionmetal ion binding
C0046982molecular_functionprotein heterodimerization activity
C0046983molecular_functionprotein dimerization activity
C0055085biological_processtransmembrane transport
C0070328biological_processtriglyceride homeostasis
C0120020molecular_functioncholesterol transfer activity
C0140359molecular_functionABC-type transporter activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005886cellular_componentplasma membrane
D0006869biological_processlipid transport
D0007584biological_processresponse to nutrient
D0009410biological_processresponse to xenobiotic stimulus
D0010949biological_processnegative regulation of intestinal phytosterol absorption
D0014850biological_processresponse to muscle activity
D0015914biological_processphospholipid transport
D0015918biological_processsterol transport
D0016020cellular_componentmembrane
D0016324cellular_componentapical plasma membrane
D0016887molecular_functionATP hydrolysis activity
D0030299biological_processintestinal cholesterol absorption
D0031667biological_processresponse to nutrient levels
D0033344biological_processcholesterol efflux
D0042626molecular_functionATPase-coupled transmembrane transporter activity
D0042632biological_processcholesterol homeostasis
D0043190cellular_componentATP-binding cassette (ABC) transporter complex
D0043235cellular_componentreceptor complex
D0045796biological_processnegative regulation of intestinal cholesterol absorption
D0046872molecular_functionmetal ion binding
D0046982molecular_functionprotein heterodimerization activity
D0046983molecular_functionprotein dimerization activity
D0055085biological_processtransmembrane transport
D0055092biological_processsterol homeostasis
D0070328biological_processtriglyceride homeostasis
D0120020molecular_functioncholesterol transfer activity
D0140359molecular_functionABC-type transporter activity
Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGERRRVSIGVQL
ChainResidueDetails
DLEU213-LEU227
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"27144356","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues86
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"27144356","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"27144356","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues128
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"27144356","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues82
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"27144356","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"27144356","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"27144356","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"27144356","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-10-15

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