8CSG
Human PRMT5:MEP50 structure with Fragment 1 and MTA Bound
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Protein arginine N-methyltransferase 5 | polymer | 645 | 73763.6 | 1 | UniProt (O14744) Pfam (PF17285) Pfam (PF05185) Pfam (PF17286) In PDB | Homo sapiens (human) | 72 kDa ICln-binding protein,Histone-arginine N-methyltransferase PRMT5,Jak-binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB1Hs |
2 | B | Methylosome protein 50 | polymer | 350 | 37862.4 | 1 | UniProt (Q9BQA1) Pfam (PF00400) In PDB | Homo sapiens (human) | MEP-50,Androgen receptor cofactor p44,WD repeat-containing protein 77,p44/Mep50 |
3 | A | 6-bromo-1H-pyrrolo[3,2-b]pyridin-5-amine | non-polymer | 212.0 | 1 | Chemie (PWL) | |||
4 | A | 5'-DEOXY-5'-METHYLTHIOADENOSINE | non-polymer | 297.3 | 1 | Chemie (MTA) | |||
5 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 3 | Chemie (PEG) | |||
6 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
7 | water | water | 18.0 | 191 | Chemie (HOH) |
Sequence modifications
A: 2 - 637 (UniProt: O14744)
B: 2 - 342 (UniProt: Q9BQA1)
PDB | External Database | Details |
---|---|---|
Met -7 | - | initiating methionine |
Asp -6 | - | expression tag |
Tyr -5 | - | expression tag |
Lys -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Asp 0 | - | expression tag |
Lys 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -7 | - | initiating methionine |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
His 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 111626.0 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 951.9 | |
All* | Total formula weight | 112577.9 |