8CR8
human Interleukin-23
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Interleukin-12 subunit beta | polymer | 325 | 36714.4 | 1 | UniProt (P29460) Pfam (PF10420) | Homo sapiens (human) | IL-12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit,CLMF p40,IL-12 subunit p40,NK cell stimulatory factor chain 2,NKSF2 |
| 2 | B (B) | Interleukin-23 subunit alpha | polymer | 196 | 21644.5 | 1 | UniProt (Q9NPF7) Pfam (PF16649) | Homo sapiens (human) | IL-23 subunit alpha,IL-23-A,Interleukin-23 subunit p19,IL-23p19 |
| 3 | C (C) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G60415BS) | |||
| 4 | D (A) | TERBIUM(III) ION | non-polymer | 158.9 | 1 | Chemie (TB) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 84 | Chemie (HOH) |
Sequence modifications
A: 23 - 328 (UniProt: P29460)
B: 22 - 189 (UniProt: Q9NPF7)
| PDB | External Database | Details |
|---|---|---|
| Met 4 | - | initiating methionine |
| Gly 5 | - | expression tag |
| Val 6 | - | expression tag |
| Lys 7 | - | expression tag |
| Val 8 | - | expression tag |
| Leu 9 | - | expression tag |
| Phe 10 | - | expression tag |
| Ala 11 | - | expression tag |
| Leu 12 | - | expression tag |
| Ile 13 | - | expression tag |
| Cys 14 | - | expression tag |
| Ile 15 | - | expression tag |
| Ala 16 | - | expression tag |
| Val 17 | - | expression tag |
| Ala 18 | - | expression tag |
| Glu 19 | - | expression tag |
| Ala 20 | - | expression tag |
| Leu 21 | - | expression tag |
| Glu 22 | - | expression tag |
| Asp 303 | Asn 303 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Gly 1 | - | expression tag |
| Trp 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Cys 4 | - | expression tag |
| Ile 5 | - | expression tag |
| Ile 6 | - | expression tag |
| Leu 7 | - | expression tag |
| Phe 8 | - | expression tag |
| Leu 9 | - | expression tag |
| Val 10 | - | expression tag |
| Ala 11 | - | expression tag |
| Thr 12 | - | expression tag |
| Ala 13 | - | expression tag |
| Thr 14 | - | expression tag |
| Gly 15 | - | expression tag |
| Val 16 | - | expression tag |
| His 17 | - | expression tag |
| Ser 18 | - | expression tag |
| Ser 19 | - | expression tag |
| Arg 20 | - | expression tag |
| Asn 21 | - | expression tag |
| His 190 | - | expression tag |
| His 191 | - | expression tag |
| His 192 | - | expression tag |
| His 193 | - | expression tag |
| His 194 | - | expression tag |
| His 195 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58358.9 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1073.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 158.9 | |
| All* | Total formula weight | 59590.8 |
