8CR8

human Interleukin-23

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Interleukin-12 subunit beta	polymer	325	36714.4	1	UniProt (P29460) Pfam (PF10420) In PDB	Homo sapiens (human)	IL-12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit,CLMF p40,IL-12 subunit p40,NK cell stimulatory factor chain 2,NKSF2
2	B	Interleukin-23 subunit alpha	polymer	196	21644.5	1	UniProt (Q9NPF7) Pfam (PF16649) In PDB	Homo sapiens (human)	IL-23 subunit alpha,IL-23-A,Interleukin-23 subunit p19,IL-23p19
3	C	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	1	In PDB GlyTouCan (G60415BS)
4	A	TERBIUM(III) ION	non-polymer		158.9	1	Chemie (TB)
5		water	water		18.0	84	Chemie (HOH)

Sequence modifications

A: 23 - 328 (UniProt: P29460)

PDB	External Database	Details
Met 4	-	initiating methionine
Gly 5	-	expression tag
Val 6	-	expression tag
Lys 7	-	expression tag
Val 8	-	expression tag
Leu 9	-	expression tag
Phe 10	-	expression tag
Ala 11	-	expression tag
Leu 12	-	expression tag
Ile 13	-	expression tag
Cys 14	-	expression tag
Ile 15	-	expression tag
Ala 16	-	expression tag
Val 17	-	expression tag
Ala 18	-	expression tag
Glu 19	-	expression tag
Ala 20	-	expression tag
Leu 21	-	expression tag
Glu 22	-	expression tag
Asp 303	Asn 303	engineered mutation

B: 22 - 189 (UniProt: Q9NPF7)

PDB	External Database	Details
Met 0	-	initiating methionine
Gly 1	-	expression tag
Trp 2	-	expression tag
Ser 3	-	expression tag
Cys 4	-	expression tag
Ile 5	-	expression tag
Ile 6	-	expression tag
Leu 7	-	expression tag
Phe 8	-	expression tag
Leu 9	-	expression tag
Val 10	-	expression tag
Ala 11	-	expression tag
Thr 12	-	expression tag
Ala 13	-	expression tag
Thr 14	-	expression tag
Gly 15	-	expression tag
Val 16	-	expression tag
His 17	-	expression tag
Ser 18	-	expression tag
Ser 19	-	expression tag
Arg 20	-	expression tag
Asn 21	-	expression tag
His 190	-	expression tag
His 191	-	expression tag
His 192	-	expression tag
His 193	-	expression tag
His 194	-	expression tag
His 195	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58358.9
Branched	Number of molecules	1
	Total formula weight	1073.0
Non-Polymers*	Number of molecules	1
	Total formula weight	158.9
All*	Total formula weight	59590.8

*Water molecules are not included.