8CDG
Crystal structure of human IL-17A cytokine in complex with macrocycle
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Interleukin-17A | polymer | 124 | 14309.1 | 2 | UniProt (Q16552) Pfam (PF06083) In PDB | Homo sapiens (human) | IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8 |
| 2 | A | (9~{S},12~{R},19~{S})-9-[[4-[[(2~{S})-2-cyclohexyl-2-(2-phenylethanoylamino)ethanoyl]amino]phenyl]methyl]-12-methyl-7,10,13,21-tetrakis(oxidanylidene)-8,11,14,20-tetrazaspiro[4.17]docosane-19-carboxylic acid | non-polymer | 787.0 | 1 | Chemie (UTF) |
Sequence modifications
A, B: 11 - 132 (UniProt: Q16552)
| PDB | External Database | Details |
|---|---|---|
| Met 9 | - | initiating methionine |
| Gly 10 | - | expression tag |
| Asp 45 | Asn 68 | conflict |
| Ser 106 | Cys 129 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28618.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 787.0 | |
| All* | Total formula weight | 29405.1 |
