8CDD

PfRH5-PfCyRPA-PfRIPR complex from Plasmodium falciparum bound to antibody Cy.003

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Rh5-interacting protein	polymer	1070	124275.1	1	UniProt (O97302)	Plasmodium falciparum 3D7	PfRipr
2	B (B)	Cysteine-rich protective antigen	polymer	343	40184.0	1	UniProt (Q8IFM8) Pfam (PF18638)	Plasmodium falciparum 3D7	Inactive sialidase CyRPA,PfCyRPA
3	C (C)	Reticulocyte-binding protein homolog 5	polymer	502	60157.0	1	UniProt (Q8IFM5) Pfam (PF18515)	Plasmodium falciparum 3D7	PfRH5
4	D (D)	Cy.003 light chain	polymer	207	22083.3	1		Gallus gallus
5	E (E)	Cy.003 heavy chain	polymer	226	23363.0	1		Gallus gallus

Sequence modifications

A: 21 - 1086 (UniProt: O97302)

PDB	External Database	Details
Gln 103	Asn 103	conflict
Gln 144	Asn 144	conflict
Gln 228	Asn 228	conflict
Gln 334	Asn 334	conflict
Gln 480	Asn 480	conflict
Gln 498	Asn 498	conflict
Gln 506	Asn 506	conflict
Gln 526	Asn 526	conflict
Gln 646	Asn 646	conflict
Gln 647	Asn 647	conflict
Gln 964	Asn 964	conflict
Gln 1021	Asn 1021	conflict
Glu 1087	-	expression tag
Pro 1088	-	expression tag
Glu 1089	-	expression tag
Ala 1090	-	expression tag

B: 29 - 362 (UniProt: Q8IFM8)

PDB	External Database	Details
Ala 147	Ser 147	conflict
Ala 324	Thr 324	conflict
Ala 340	Thr 340	conflict
Gly 363	-	expression tag
Gly 364	-	expression tag
Gly 365	-	expression tag
Gly 366	-	expression tag
Ser 367	-	expression tag
Glu 368	-	expression tag
Pro 369	-	expression tag
Glu 370	-	expression tag
Ala 371	-	expression tag

C: 25 - 526 (UniProt: Q8IFM5)

PDB	External Database	Details
Tyr 203	Cys 203	conflict
Ala 216	Thr 216	conflict
Ala 299	Thr 299	conflict

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	270062.4
All*	Total formula weight	270062.4

*Water molecules are not included.